The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones Thomas R. Cech, Joan A. Steitz  Cell  Volume 157, Issue 1, Pages 77-94 (March 2014) DOI: 10.1016/j.cell.2014.03.008 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Noncoding RNAs Function in Diverse Contexts Noncoding RNAs function in all domains of life, regulating gene expression from transcription to splicing to translation and contributing to genome organization and stability. Self-splicing RNAs, ribosomes, and riboswitches function in both eukaryotes and bacteria. Archaea (not shown) also utilize ncRNA systems including ribosomes, riboswitches, snoRNPs, and CRISPR. Orange strands, ncRNA performing the action indicated; red strands, the RNA acted upon by the ncRNA. Blue strands, DNA. Triangle, small-molecule metabolite bound by a riboswitch. Ovals indicate protein components of an RNP, such as the spliceosome (white oval), ribosome (two purple subunits), or other RNPs (yellow ovals). Because of the importance of RNA structure in these ncRNAs, some structures are shown but they are not meant to be realistic. Cell 2014 157, 77-94DOI: (10.1016/j.cell.2014.03.008) Copyright © 2014 Elsevier Inc. Terms and Conditions