A Retrospective Review of the Outcome after Second or Subsequent Allogeneic Transplantation Meirav Kedmi, Igor B. Resnick, Liliane Dray, Memet Aker,

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Presentation transcript:

A Retrospective Review of the Outcome after Second or Subsequent Allogeneic Transplantation Meirav Kedmi, Igor B. Resnick, Liliane Dray, Memet Aker, Simcha Samuel, Benjamin Gesundheit, Shimon Slavin, Reuven Or, Michael Y. Shapira Biology of Blood and Marrow Transplantation Volume 15, Issue 4, Pages 483-489 (April 2009) DOI: 10.1016/j.bbmt.2009.01.009 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 OS and DFS of all the 144 patients who underwent more than 1 allogeneic SCT. Most patients surviving the second procedure are in continuous remission. Biology of Blood and Marrow Transplantation 2009 15, 483-489DOI: (10.1016/j.bbmt.2009.01.009) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 OS of patients according to basic disease. It is clear that patients who underwent the second allogeneic SCT because of a nonmalignant condition survived better then patients with malignant diseases. Biology of Blood and Marrow Transplantation 2009 15, 483-489DOI: (10.1016/j.bbmt.2009.01.009) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 (A) Survival according to the indication for the second SCT. Patients who were transplanted because of persistent/relapse of their basic disease survived significantly less than those who were transplanted for other reasons. (B) Survival according to donor matching in the second SCT—patients who had the second transplant from a matched donor survived significantly more then those who were transplanted from a mismatched donor. Biology of Blood and Marrow Transplantation 2009 15, 483-489DOI: (10.1016/j.bbmt.2009.01.009) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 OS from second SCT according to conditioning regimen. Patients who underwent RIC survived significantly better then those who underwent myeloablative conditioning. Biology of Blood and Marrow Transplantation 2009 15, 483-489DOI: (10.1016/j.bbmt.2009.01.009) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions