Subchondral bone turnover, but not bone volume, is increased in early stage osteoarthritic lesions in the human hip joint R. Klose-Jensen, L.B. Hartlev,

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Presentation transcript:

Subchondral bone turnover, but not bone volume, is increased in early stage osteoarthritic lesions in the human hip joint R. Klose-Jensen, L.B. Hartlev, L.W.T. Boel, M.B. Laursen, K. Stengaard-Pedersen, K.K. Keller, E.-M. Hauge Osteoarthritis and Cartilage Volume 23, Issue 12, Pages 2167-2173 (December 2015) DOI: 10.1016/j.joca.2015.06.001 Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Design-based stereological methods. Using systematic uniform random sampling, the Cavalieri estimator and vertical sections to investigate entire undecalcified human femoral heads. (A): the femoral heads random section was chosen by random rotation of the femoral head around the vertical axis. The red arrow hits the random number 27. (B): black lines indicate the 7-mm thick slices parallel cuts. (C): half block 7-mm thick slices were embedded in plastic. (D): From each plastic block, 7-μm-thick sections were cut on the microtome and stained with Masson-Goldner trichrome. Osteoarthritis and Cartilage 2015 23, 2167-2173DOI: (10.1016/j.joca.2015.06.001) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Goldner-trichrome stained vertical uniform random sections of a half femoral head divided into subarticular bone regions according to overlying cartilage degeneration OARSI 0–2 (green), OARSI 3–4 (blue), OARSI 5–6 (red), and central bone region (yellow). Osteoarthritis and Cartilage 2015 23, 2167-2173DOI: (10.1016/j.joca.2015.06.001) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Bone volume, erosive and osteoid surface from the subarticular bone region of the femoral head in both osteoarthritic patients and the control group. Boxes denotes the median and interquantile range of the groups. Non-parametric test was used in C and D which was not normally distributed. Osteoarthritis and Cartilage 2015 23, 2167-2173DOI: (10.1016/j.joca.2015.06.001) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Bone volume, erosive and osteoid surface from the central bone region of the femoral head in both osteoarhritic patients and the control group. Boxes denotes the median and interquantile range of the groups. Non-parametric test was used in C and D which was not normally distributed. Osteoarthritis and Cartilage 2015 23, 2167-2173DOI: (10.1016/j.joca.2015.06.001) Copyright © 2015 Osteoarthritis Research Society International Terms and Conditions