Volume 9, Issue 3, Pages R81-R82 (February 1999) General anesthesia  Howard A. Nash  Current Biology  Volume 9, Issue 3, Pages R81-R82 (February 1999) DOI: 10.1016/S0960-9822(99)80055-4

Figure 1 VGAs alter electrical activity in many parts of the brain. (a) Recordings from the cerebral cortex of cats show halothane induction of clusters of high-amplitude, 8–14 Hz EEG waves. (Reproduced with permission from Keifer JC et al., Anesthesiology 1996, 84:945-954.) (b) Recordings from slices of rat hippocampus (a structure deep within the brain) show that halothane depresses bursts of 150–200 Hz oscillations (Reproduced with permission from Draguhn A et al., Nature 1998, 394:189-192.) (c) Recordings from the ventral root of isolated rat spinal cords show isoflurane depresses the slow (2–10 sec) response to dorsal root stimulation. (Reproduced with permission from Savola MK et al., Anesthesiology 1991, 75:489-498.) Current Biology 1999 9, R81-R82DOI: (10.1016/S0960-9822(99)80055-4)

Figure 2 VGAs alter regional brain metabolism. These autoradiograms are of frozen brain sections from rats that were infused intravenously with radiolabelled deoxyglucose for 50 mins while (a) under control conditions, or (b) under isoflurane anesthesia. Arrows point to regions of the brain with prominent decreases in glucose uptake (auditory cortex and medial geniculate) or prominent increases (substantia nigra pars compacta and fasciculus retroflexus). (Photograph kindly provided by Carlo Ori, reproduced with permission from Ori C et al., Anesthesiology 1986, 65:152-156.) Current Biology 1999 9, R81-R82DOI: (10.1016/S0960-9822(99)80055-4)