Volume 154, Issue 5, Pages e3 (April 2018)

Slides:

Advertisements

Similar presentations

Increased Levels of Arginase in Patients With Acute Hepatitis B Suppress Antiviral T Cells Elena Sandalova, Diletta Laccabue, Carolina Boni, Tsunamasa.

Advertisements

Volume 142, Issue 4, Pages (April 2012)

Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus James Y. Dai, Jean de Dieu Tapsoba,

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Risk of Esophageal Adenocarcinoma and Mortality in Patients With Barrett's Esophagus: A Systematic Review and Meta-analysis Marjolein Sikkema, Pieter.

Volume 148, Issue 2, Pages (February 2015)

Covering the Cover Gastroenterology

Volume 17, Issue 10, Pages (October 2016)

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Covering the Cover Gastroenterology

Cost-Effectiveness of Access Expansion to Treatment of Hepatitis C Virus Infection Through Primary Care Providers Thilo Rattay, Ian P. Dumont, Hauke.

Volume 137, Issue 3, Pages (September 2009)

Aaron P. Thrift, Thomas L. Vaughan, Lesley A. Anderson, David C

American Gastroenterological Association Technical Review on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts James M. Scheiman,

Nadir Arber, Bernard Levin Gastroenterology

Volume 149, Issue 3, Pages e3 (September 2015)

Body Composition and Barrett’s Esophagus

Cause-Specific Mortality of People With Barrett's Esophagus Compared With the General Population: A Population-Based Cohort Study Masoud Solaymani–Dodaran,

Volume 148, Issue 7, Pages (June 2015)

Volume 154, Issue 8, Pages e5 (June 2018)

Amnon Sonnenberg, Richard H. Lash, Robert M. Genta Gastroenterology

American Gastroenterological Association Institute Technical Review on the Management of Gastroesophageal Reflux Disease Peter J. Kahrilas, Nicholas.

A Model to Determine Absolute Risk for Esophageal Adenocarcinoma

Volume 142, Issue 2, Pages (February 2012)

Success as a PhD in Gastroenterology

Volume 146, Issue 4, Pages e1 (April 2014)

Volume 154, Issue 4, Pages e1 (March 2018)

Unusual Case of an Upset Stomach

Volume 153, Issue 3, Pages e16-e17 (September 2017)

Volume 150, Issue 4, Pages (April 2016)

Yutaka Tomizawa, Lei Zhao, Leslie W. Yang Gastroenterology

Personalizing Colorectal Cancer Screening: A Systematic Review of Models to Predict Risk of Colorectal Neoplasia Gene K. Ma, Uri Ladabaum Clinical Gastroenterology.

Sibu Varghese, Pierre Lao–Sirieix, Rebecca C. Fitzgerald

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus Jing Dong, David M.

Volume 139, Issue 6, Pages e15 (December 2010)

Esophageal Adenocarcinoma 10 Years After Surgical Resection of Barrett’s Esophagus: Unusual Presentation as Subepithelial Tumor Andreas Probst, Tina.

A Multibiomarker Risk Score Helps Predict Risk for Barrett’s Esophagus

Risk of Esophageal Adenocarcinoma and Mortality in Patients With Barrett's Esophagus: A Systematic Review and Meta-analysis Marjolein Sikkema, Pieter.

Volume 136, Issue 4, Pages e2 (April 2009)

Endoscopic Therapy for Barrett's Esophagus

Aaron P. Thrift, PhD Clinical Gastroenterology and Hepatology

Volume 135, Issue 1, Pages (July 2008)

Volume 142, Issue 4, Pages (April 2012)

Laura Rotundo, Sushil Ahlawat Gastroenterology

The 75th Diamond Anniversary of Gastroenterology: 1943–2018

A Common Disease With an Unusual Complication of Acute Abdomen

Genetic Testing for Hereditary Colorectal Cancer: Challenges in Identifying, Counseling, and Managing High-Risk Patients Elena M. Stoffel, Anu Chittenden

Constrained Score Statistics Identify Genetic Variants Interacting with Multiple Risk Factors in Barrett’s Esophagus James Y. Dai, Jean de Dieu Tapsoba,

Hashem El–Serag, Anna S.F. Lok, David L. Thomas Gastroenterology

Prevalence of Eosinophilic Esophagitis in the United States

Factors Associated With Progression of Barrett’s Esophagus: A Systematic Review and Meta-analysis Rajesh Krishnamoorthi, Siddharth Singh, Karthik Ragunathan,

Ashwin N. Ananthakrishnan, David Lieberman Gastroenterology

Rebecca M. Lovell, Alexander C. Ford

Gastric Rupture Gastroenterology

The Rise and Fall (and Rise?) of Endoscopic Anti-Reflux Procedures

The Dawning of a New Editorial Board for Gastroenterology

Raffaele Pezzilli, MD, Giulio Cariani, MD Gastroenterology

Association of Barrett's Esophagus With Type II Diabetes Mellitus: Results From a Large Population-based Case-Control Study Prasad G. Iyer, Bijan J.

Volume 156, Issue 5, Pages (April 2019)

Risks Associated With Anesthesia Services During Colonoscopy

Electronic Clinical Challenges and Images in GI

Volume 155, Issue 6, Pages (December 2018)

Volume 139, Issue 6, Pages e1 (December 2010)

Esophageal Tumor After Radical Surgery for Gastric Cancer

Cancer Costs Projected to Reach at Least $158 Billion in 2020

Volume 138, Issue 6, Pages (May 2010)

Electronic Clinical Challenges and Images in GI

Electronic Clinical Challenges and Images in GI

Statin Use Is Associated With a Decreased Risk of Barrett’s Esophagus

Unrelenting Abdominal Pain after Recent Initiation of a Direct Oral Anticoagulant: A Cause for Concern Nicholas R. Crews, Nabil Fayad Gastroenterology

Presentation transcript:

Volume 154, Issue 5, Pages 1273-1281.e3 (April 2018) Determining Risk of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants Jing Dong, Matthew F. Buas, Puya Gharahkhani, Bradley J. Kendall, Lynn Onstad, Shanshan Zhao, Lesley A. Anderson, Anna H. Wu, Weimin Ye, Nigel C. Bird, Leslie Bernstein, Wong-Ho Chow, Marilie D. Gammon, Geoffrey Liu, Carlos Caldas, Paul D. Pharoah, Harvey A. Risch, Prasad G. Iyer, Brian J. Reid, Laura J. Hardie, Jesper Lagergren, Nicholas J. Shaheen, Douglas A. Corley, Rebecca C. Fitzgerald, David C. Whiteman, Thomas L. Vaughan, Aaron P. Thrift Gastroenterology Volume 154, Issue 5, Pages 1273-1281.e3 (April 2018) DOI: 10.1053/j.gastro.2017.12.003 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 The receiver operating characteristic curves associated with risk prediction models for (A) BE and (B) EAC. Demographic/lifestyle model includes age, sex, smoking, BMI, and use of NSAIDs. Gastroenterology 2018 154, 1273-1281.e3DOI: (10.1053/j.gastro.2017.12.003) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 1 Distributions of the PRS in the BEACON and UK datasets (cases and controls). Gastroenterology 2018 154, 1273-1281.e3DOI: (10.1053/j.gastro.2017.12.003) Copyright © 2018 AGA Institute Terms and Conditions

Supplementary Figure 2 Box-plots of the PRS separately in cases (BE and EAC) and controls. Gastroenterology 2018 154, 1273-1281.e3DOI: (10.1053/j.gastro.2017.12.003) Copyright © 2018 AGA Institute Terms and Conditions