Interaction of physostigmine and alfentanil in a human pain model†

Slides:

Advertisements

Similar presentations

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Advertisements

Effects of staff training on the care of mechanically ventilated patients: a prospective cohort study F. Bloos, S. Müller, A. Harz, M. Gugel, D. Geil,

Impact of xenon anaesthesia in isolated cardiopulmonary bypass on very early leucocyte and platelet activation and clearance: a randomized, controlled.

Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia M Hara, K Masui, D.J. Eleveld,

Effects of maintaining a remifentanil infusion on the recovery profiles during emergence from anaesthesia and tracheal extubation J.-S. Nho, S.-Y. Lee,

Intranasal application of xenon: describing the pharmacokinetics in experimental animals and the increased pain tolerance within a placebo-controlled.

Non-opioid analgesics in adults after major surgery: systematic review with network meta-analysis of randomized trials V Martinez, H Beloeil, E Marret,

C.-A. Ewaldsson, R.G. Hahn British Journal of Anaesthesia

Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation† G.A. Hans, S.M. Lauwick, A.

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

Parkinson's disease and anaesthesia

Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials V. Martinez, L. Guichard,

Pharmacokinetic and pharmacodynamic interactions in anaesthesia

M. M. R. F. Struys, M. Sahinovic, B. J. Lichtenbelt, H. E. M

Pharmacokinetic/pharmacodynamic model for unfractionated heparin dosing during cardiopulmonary bypass X. Delavenne, E. Ollier, S. Chollet, F. Sandri,

Efficacy of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery S.Y. Kim, J.M. Kim, J.H. Lee,

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery:

Differential effects of lidocaine and remifentanil on response to the tracheal tube during emergence from general anaesthesia J.H. Lee, B.-N. Koo, J.-J.

L. Pain, A. Launoy, N. Fouquet, P. Oberling

Kenneth A Follett, MD, PhD, Claus P Naumann, MD

M. Boutonnet, V. Faitot, A. Katz, L. Salomon, H. Keita

J.-Y. Hwang, H.-S. Na, Y.-T. Jeon, Y.-J. Ro, C.-S. Kim, S.-H. Do

R Wengritzky, T Mettho, P.S. Myles, J Burke, A Kakos

Codeine phosphate in paediatric medicine

Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children C. Jeleazcov, H. Ihmsen,

Chronic opioid therapy for non-cancer pain

Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats A Dahan, A Yassen, H Bijl, R Romberg, E Sarton, L.

Development of atelectasis and arterial to end-tidal Pco2-difference in a porcine model of pneumoperitoneum C.M. Strang, T. Hachenberg, F. Fredén, G.

T. Iirola, H. Ihmsen, R. Laitio, E. Kentala, R. Aantaa, J. -P

M Ranucci, E Baryshnikova British Journal of Anaesthesia

A. Vasudevan, C.E. Snowman, S. Sundar, T.W. Sarge, P.E. Hess

Preoperative butorphanol and flurbiprofen axetil therapy attenuates remifentanil-induced hyperalgesia after laparoscopic gynaecological surgery: a randomized.

Efficacy of intravenous magnesium in neuropathic pain

D.H.J. Davis, M. Oliver, A.J. Byrne British Journal of Anaesthesia

EEG-controlled closed-loop dosing of propofol in rats

High inspired oxygen concentration increases the speed of onset of remifentanil- induced respiratory depression A Dahan, M Douma, E Olofsen, M Niesters

Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious.

Pharmacodynamic response modelling of arterial blood pressure in adult volunteers during propofol anaesthesia C. Jeleazcov, M. Lavielle, J. Schüttler,

Arginine-vasopressin attenuates beneficial norepinephrine effect on jejunal mucosal tissue oxygenation during endotoxinaemia S. Maier, W. Hasibeder,

A. M. El-Hennawy, A. M. Abd-Elwahab, A. M. Abd-Elmaksoud, H. S

Postoperative intravenous morphine titration

V Minville, O Fourcade, J.-P. Girolami, I Tack

The novel Kv1.5 channel blocker vernakalant for successful treatment of new-onset atrial fibrillation in a critically ill abdominal surgical patient

Double-blind, randomized, placebo-controlled trial comparing rofecoxib with dexketoprofen trometamol in surgical dentistry Jackson I.D. , Heidemann B.H.

Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial A.F. Merry, R.D. Gibbs, J. Edwards,

N.A. Manering, T. Reuter, H. Ihmsen, D.C. Yeomans, A. Tzabazis

Do old pharmacokinetic parameter estimates predict new data?

F.H. Engbers, N Sutcliffe, G Kenny, S Schraag

Use of L’Abbé and pooled calibration plots to assess the relationship between severity of illness and effectiveness in studies of corticosteroids for.

Routine screening for pain combined with a pain treatment protocol in head and neck cancer: a randomised controlled trial J.E. Williams, J. Peacock,

Tranexamic acid in hip fracture surgery: a randomized controlled trial

A unique effect of propofol on the jaw opening reflex

Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis E.D. McNicol,

Efficacy of butylscopolamine for the treatment of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study

J.E. Spiegel, A. Vasudevan, Y. Li, P.E. Hess

J Lee, S Gupta, C Price, A.P. Baranowski

Chronic widespread pain, including fibromyalgia: a pathway for care developed by the British Pain Society J. Lee, B. Ellis, C. Price, A.P. Baranowski

P Schramm, K Engelhard, A Scherhag, F Schier, C Werner

Effects of remifentanil on cardiovascular and bispectral index responses to endotracheal intubation in severe pre-eclamptic patients undergoing Caesarean.

Comparison of sub-Tenon’s block with i. v

Sepsis and the heart British Journal of Anaesthesia

Cross-tolerance between spinal neostigmine and morphine in the rat

Comparison of relaxant effects of propofol on methacholine-induced bronchoconstriction in dogs with and without vagotomy S Kabara, K Hirota, E Hashiba,

A huffing manoeuvre, immediately before induction of anaesthesia, prevents fentanyl- induced coughing: a prospective, randomized, and controlled study

Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers† B.A. Chizh, M.

Regional anaesthesia to improve pain outcomes in paediatric surgical patients: a qualitative systematic review of randomized controlled trials S. Suresh,

Effects of magnesium sulphate on intraoperative neuromuscular blocking agent requirements and postoperative analgesia in children with cerebral palsy

Hypothermic responses to infection are inhibited by α2-adrenoceptor agonists with possible clinical implications S. Tolchard, P.A. Burns, D.J. Nutt,

Voltage changes in the lithium dilution cardiac output sensor after exposure to blood from horses given xylazine T.D. Ambrisko, Y. Moens British Journal.

Analysis of pharmacodynamic interaction of sevoflurane and propofol on bispectral index during general anaesthesia using a response surface model J.C.

Presentation transcript:

Interaction of physostigmine and alfentanil in a human pain model† A.P. Wehrfritz, H. Ihmsen, S. Schmidt, C. Müller, J. Filitz, J. Schüttler, W. Koppert British Journal of Anaesthesia Volume 104, Issue 3, Pages 359-368 (March 2010) DOI: 10.1093/bja/aep372 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Schematic illustration of the experimental protocol. Four separate treatment trials were performed. The subjects received i.v. infusions of physostigmine, alfentanil, a combination of both, or saline as a control in a randomized order. The drugs were delivered by a continuous infusion lasting 15 min (physostigmine) or 2 min (alfentanil) and starting 30 min (physostigmine) or 35 min (alfentanil) after the onset of the electrical stimulation. British Journal of Anaesthesia 2010 104, 359-368DOI: (10.1093/bja/aep372) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Pain ratings (a) and the areas of pinprick-hyperalgesia (b) for the four treatments. Data were normalized to baseline and are expressed as mean±se. British Journal of Anaesthesia 2010 104, 359-368DOI: (10.1093/bja/aep372) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 Measured and predicted time courses of the analgesic effect after administration of alfentanil and physostigmine for the two tested interaction models. Model 1, as defined by equations (3) and (4), was less appropriate than model 2, as defined by equations (6) and (7). British Journal of Anaesthesia 2010 104, 359-368DOI: (10.1093/bja/aep372) Copyright © 2010 The Author(s) Terms and Conditions

Fig 4 Placebo-corrected and normalized analgesic (a–c) and antihyperalgesic (d–f) effects for alfentanil (a, d), physostigmine (b, e), and a combination of both (c, f), respectively. The predictions of the final pharmacodynamic model are drawn with solid lines. Data are expressed as mean±se. British Journal of Anaesthesia 2010 104, 359-368DOI: (10.1093/bja/aep372) Copyright © 2010 The Author(s) Terms and Conditions

Fig 5 Isoboles for half-maximum analgesic (a) and antihyperalgesic (b) effect. The thin lines are the isoboles of the individual subjects, the bold line is the isobole obtained with the population parameters. The dashed line shows the line of additive interaction. British Journal of Anaesthesia 2010 104, 359-368DOI: (10.1093/bja/aep372) Copyright © 2010 The Author(s) Terms and Conditions

Fig 6 Dose–response curves for the analgesic (a) and antihyperalgesic (b) effect of alfentanil and physostigmine. British Journal of Anaesthesia 2010 104, 359-368DOI: (10.1093/bja/aep372) Copyright © 2010 The Author(s) Terms and Conditions