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Nat. Rev. Urol. doi:10.1038/nrurol.2017.134 Figure 1 Multiple glands with high-grade prostatic intraepithelial neoplasia (HGPIN) on needle biopsy Figure 1 | Multiple glands with high-grade prostatic intraepithelial neoplasia (HGPIN) on needle biopsy. HGPIN glands (arrows) are architecturally benign (large with papillary infolding) with nuclear atypia. Notably, HGPIN does not show an infiltrative growth pattern. The risk of cancer following HGPIN on prostate biopsy is ∼20–30%, which is not significantly higher than that following a benign biopsy. Tosoian, J. J. et al. (2017) Managing high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands on prostate biopsy Nat. Rev. Urol. doi:10.1038/nrurol.2017.134