Volume 139, Issue 1, Pages (July 2010)

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Volume 139, Issue 1, Pages 36-47 (July 2010) Regional Brain Activity in Functional Dyspepsia: A H215O-PET Study on the Role of Gastric Sensitivity and Abuse History Lukas Van Oudenhove, Joris Vandenberghe, Patrick Dupont, Brecht Geeraerts, Rita Vos, Stijn Dirix, Koen Van Laere, Guy Bormans, Dominique Vanderghinste, Koen Demyttenaere, Benjamin Fischler, Jan Tack Gastroenterology Volume 139, Issue 1, Pages 36-47 (July 2010) DOI: 10.1053/j.gastro.2010.04.015 Copyright © 2010 Terms and Conditions

Figure 1 (A) Overview of ventral PCC (vPCC) cluster that is significantly more activated in normosensitive compared to hypersensitive FD patients during baseline (contrast Baselinenormo > Baselinehyper). (B) Overview and plot of contrast estimates from (Distension > Baseline)normo > (Distension > Baseline)hyper at the right anterior MCC (aMCC) local maximum, showing the deactivation during distension in hypersensitives, while no change is observed in normosensitives. (C) Overview and plot of contrast estimates from (Distension > Baseline)normo > (Distension > Baseline)hyper at the right Rolandic operculum local maximum, showing the deactivation during distension in hypersensitives, while activation is observed in normosensitives. Color bars represent t values. Gastroenterology 2010 139, 36-47DOI: (10.1053/j.gastro.2010.04.015) Copyright © 2010 Terms and Conditions

Figure 2 (A) Overview of hippocampus/amygdala cluster that is significantly more activated in patients without history of abuse compared to patients with history of abuse during baseline (contrast (Baselinenoabuse> Baselineabuse); 32.1% of the cluster is overlapping with the hippocampus, 21% with the amygdala. Color bar represents t values. (B) Plot of contrast estimates from (Distension > Baseline)abuse> (Distension > Baseline)noabuse at the right hippocampus/amygdala local maximum (Table 9), showing the lack of hippocampus/amygdala deactivation during distension in abused compared to nonabused patients. Gastroenterology 2010 139, 36-47DOI: (10.1053/j.gastro.2010.04.015) Copyright © 2010 Terms and Conditions