Volume 64, Pages S64-S70 (October 2003)

Slides:



Advertisements
Similar presentations
Volume 81, Issue 11, Pages (June 2012)
Advertisements

Volume 62, Pages S12-S22 (December 2002)
Volume 65, Issue 1, Pages (January 2004)
Volume 60, Issue 3, Pages (September 2001)
Lymphatic vessels develop during tubulointerstitial fibrosis
Osteopontin expression in acute renal allograft rejection
Volume 81, Issue 11, Pages (June 2012)
Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy  Shi-Nong Wang, Janine Lapage, Raimund.
Volume 68, Issue 2, Pages (August 2005)
Viper venom for diabetic nephropathy
Obstructive nephropathy: Insights from genetically engineered animals
Volume 58, Issue 4, Pages (October 2000)
Volume 62, Issue 1, Pages (July 2002)
Viper venom for diabetic nephropathy
Volume 64, Issue 1, Pages (July 2003)
Volume 83, Issue 5, Pages (May 2013)
Volume 65, Issue 1, Pages (January 2004)
Volume 61, Issue 3, Pages (March 2002)
Volume 62, Issue 1, Pages (July 2002)
Volume 56, Issue 6, Pages (December 1999)
JAK/STAT signaling in renal diseases
Tubular NF-κB and AP-1 activation in human proteinuric renal disease
Volume 86, Issue 6, Pages (December 2014)
Volume 69, Issue 1, Pages (January 2006)
The intrarenal renin-angiotensin system in hypertension
Volume 63, Issue 2, Pages (February 2003)
Volume 59, Issue 5, Pages (May 2001)
Marie Claire Gubler, Corinne Antignac  Kidney International 
Volume 63, Issue 5, Pages (May 2003)
Volume 64, Pages S46-S51 (October 2003)
Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy  Shinya Mizuno, Kunio Matsumoto, Toshikazu Nakamura 
Volume 60, Issue 3, Pages (September 2001)
Volume 64, Pages S39-S45 (October 2003)
Volume 63, Issue 2, Pages (February 2003)
Volume 57, Issue 1, Pages (January 2000)
Volume 55, Issue 2, Pages (February 1999)
Calcium citrate ameliorates the progression of chronic renal injury
Volume 61, Issue 6, Pages (June 2002)
Lymphatic vessels develop during tubulointerstitial fibrosis
Volume 60, Issue 6, Pages (December 2001)
Volume 57, Issue 1, Pages (January 2000)
Volume 56, Issue 2, Pages (August 1999)
Volume 59, Issue 3, Pages (March 2001)
Osteopontin in diabetic nephropathy: signpost or road?
Expression of connective tissue growth factor in human renal fibrosis
Volume 74, Issue 4, Pages (August 2008)
Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver- derived angiotensinogen  David I. Ortiz-Melo, Robert F. Spurney 
C5b-9 regulates peritubular myofibroblast accumulation in experimental focal segmental glomerulosclerosis  Gopala K. Rangan, Jeffrey W. Pippin, William.
Volume 62, Pages S12-S22 (December 2002)
Volume 75, Issue 6, Pages (March 2009)
Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy  Carolina Lavoz, Yenniffer Sánchez Matus,
Volume 82, Issue 2, Pages (July 2012)
Volume 70, Issue 8, Pages (October 2006)
Volume 59, Issue 5, Pages (May 2001)
Volume 64, Pages S33-S38 (October 2003)
Volume 64, Pages S21-S26 (October 2003)
Volume 65, Issue 6, Pages (June 2004)
Volume 69, Issue 11, Pages (June 2006)
Volume 60, Issue 5, Pages (November 2001)
Volume 58, Issue 4, Pages (October 2000)
Volume 59, Issue 5, Pages (May 2001)
Increased importin α protein expression in diabetic nephropathy
Volume 68, Pages S98-S102 (December 2005)
Volume 65, Issue 2, Pages (February 2004)
Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats
Volume 67, Issue 6, Pages (June 2005)
Volume 72, Issue 11, Pages (December 2007)
Volume 58, Issue 6, Pages (December 2000)
Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy  Shi-Nong Wang, Janine Lapage, Raimund.
Volume 79, Issue 11, Pages (June 2011)
Presentation transcript:

Volume 64, Pages S64-S70 (October 2003) Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy  Sergio Mezzano, Alejandra Droguett, M. Eugenia Burgos, Leopoldo G. Ardiles, Claudio A. Flores, Claudio A. Aros, Italo Caorsi, Carlos P. Vío, Marta Ruiz-Ortega, Jesús Egido  Kidney International  Volume 64, Pages S64-S70 (October 2003) DOI: 10.1046/j.1523-1755.64.s86.12.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Expression of components of the renin-angiotensin system. Shown are serial sections of one representative case of diabetes, and one normal kidney section. In contrast to that observed in the normal kidney, in which angiotensin-converting enzyme (ACE) was weakly expressed in the brush border of proximal tubules, a marked up-regulation was noted in some tubules, and ACE neoinduction appeared in interstitial cells, mainly α-actin positive cells. Angiotensin II (Ang II) immunostaining was detected in tubular and interstitial infiltrating cells. In comparison with the widespread distribution of AT1 and AT2 receptors in normal kidney, in diabetic nephropathy (DN) the staining score for AT1 was significantly decreased as compared with the AT2 receptor. Magnification ×200 and ×400 normal kidney vs. diabetic kidney, respectively. Kidney International 2003 64, S64-S70DOI: (10.1046/j.1523-1755.64.s86.12.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Activated nuclear factor kappa B (NFκB) by Southwestern histochemistry, osteopontin (OPN), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation, normal T cell expressed and secreted (RANTES) (protein and mRNA) in human diabetic nephropathy. Activated NFκB was mainly detected in (A) tubular epithelial cells and, to a lesser extent, in some glomerular and interstitial cells. (B) Osteopontin, (C and D) MCP-1, (E and F) RANTES protein, and mRNA expressions were detected in the same tubular cells. Immunohistochemical staining for (G) α-smooth muscle actin denotes interstitial myofibroblasts, and (H) angiotensin-converting enzyme (ACE) neoinduction appears in interstitial cells. The different techniques were performed as described in Methods. Kidney International 2003 64, S64-S70DOI: (10.1046/j.1523-1755.64.s86.12.x) Copyright © 2003 International Society of Nephrology Terms and Conditions