Volume 11, Issue 6, Pages 453-465 (June 2010) With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging  Pankaj Kapahi, Di Chen, Aric N. Rogers, Subhash D. Katewa, Patrick Wai-Lun Li, Emma L. Thomas, Lutz Kockel  Cell Metabolism  Volume 11, Issue 6, Pages 453-465 (June 2010) DOI: 10.1016/j.cmet.2010.05.001 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Schematic of the TOR Signaling Network TORC1 integrates intra- and extracellular environmental cues through discrete signaling modules that sense and relay diverse inputs to a central “signaling core” (in green). This figure summarizes biochemical evidence from various studies that have identified the inputs and outputs of TORC1. Various outputs (in gray) that keep cellular growth in balance with the environment are regulated by TORC1. See the main text for details. Cell Metabolism 2010 11, 453-465DOI: (10.1016/j.cmet.2010.05.001) Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 2 TOR Pathway, a Conserved Mediator of Life Span Extension in Multiple Species The diagram represents the genetic interactions in the TOR signaling network that execute life span extension in yeast, worms, flies, and mice. The diagram summarizes the life span data for genes in the TOR signaling pathway or those that demonstrate a genetic interaction with mutants in the TOR pathway. The shaded area refers to components of the TOR pathway that show conserved effects on life span extension in different species. See the main text for details. Cell Metabolism 2010 11, 453-465DOI: (10.1016/j.cmet.2010.05.001) Copyright © 2010 Elsevier Inc. Terms and Conditions