Volume 136, Issue 7, Pages 2159-2168 (June 2009) Efficacy of L-Ornithine L-Aspartate in Acute Liver Failure: A Double-Blind, Randomized, Placebo-Controlled Study  Subrat Kumar Acharya, Vikram Bhatia, Vishnubhatla Sreenivas, Shankar Khanal, Subrat Kumar Panda  Gastroenterology  Volume 136, Issue 7, Pages 2159-2168 (June 2009) DOI: 10.1053/j.gastro.2009.02.050 Copyright © 2009 AGA Institute Terms and Conditions

Figure 1 Kaplan–Meier curves showing the cumulative survival percentage of ALF patients randomized to placebo or LOLA infusion (P = .2322 by the log rank test at 1 df). Gastroenterology 2009 136, 2159-2168DOI: (10.1053/j.gastro.2009.02.050) Copyright © 2009 AGA Institute Terms and Conditions

Figure 2 Log transformed mean ammonia levels among patients randomized to placebo or LOLA during the initial 6 days. Gastroenterology 2009 136, 2159-2168DOI: (10.1053/j.gastro.2009.02.050) Copyright © 2009 AGA Institute Terms and Conditions

Figure 3 Time trend in ammonia levels over initial week after admission among patients randomized to placebo and LOLA treatment. The patients have been stratified based on a high (≥124 μmol/L) and low (<124 μmol/L) baseline ammonia levels. The time points represent mean ammonia levels in micromolars. A lack of effect of LOLA in lowering ammonia levels is evident regardless of baseline ammonia levels. Gastroenterology 2009 136, 2159-2168DOI: (10.1053/j.gastro.2009.02.050) Copyright © 2009 AGA Institute Terms and Conditions