J. Desrochers, M.W. Amrein, J.R. Matyas Osteoarthritis and Cartilage

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Viscoelasticity of the articular cartilage surface in early osteoarthritis J. Desrochers, M.W. Amrein, J.R. Matyas Osteoarthritis and Cartilage Volume 20, Issue 5, Pages 413-421 (May 2012) DOI: 10.1016/j.joca.2012.01.011 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative unprocessed force and indentation depth vs time data for one second before and after surface contact. Thick dashed curve indicates cantilever position; thin solid curve indicates cantilever identation force. Osteoarthritis and Cartilage 2012 20, 413-421DOI: (10.1016/j.joca.2012.01.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 A) Representative 5× retardance image showing 3 ROI from which retardance data were used. B) Retardance data from a ROI showing superficial zone and tidemark (blue line). C) Representative 20× retardance image, showing topmost 25 μm of the superficial surface (single pixel yellow lines) from same location as shown in A). Vital staining of adjacent sections showed that cell lacunae observed throughout the superficial zone (white arrows) were occupied by viable chondrocytes (data not shown). Scale bar, 100 μm; maximum retardance (white), 50 nm. Osteoarthritis and Cartilage 2012 20, 413-421DOI: (10.1016/j.joca.2012.01.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Representative curve of Ei vs t from a single creep test on Ctl cartilage. Grey curve indicates raw data points; black line indicates best fit based on three-element model. Osteoarthritis and Cartilage 2012 20, 413-421DOI: (10.1016/j.joca.2012.01.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Representative photomicrographs of safranin-O stained cartilage sections. Images demonstrate changes in superficial zone proteoglycan staining in Ctl (A and C) compared to CCLx (B and D) cartilage. In image B, the reduction in safranin-O staining at the superficial zone is evident; whereas in image D there is an increase in staining in the superficial zone compared to the Ctl image. Cartilage sections illuminated with monochromatic light (470–550 nm) by inserting Kodak Wratten filters, (#102 and #44A) into the light path. Scale bar, 100 μm. Osteoarthritis and Cartilage 2012 20, 413-421DOI: (10.1016/j.joca.2012.01.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions