Microbial Persistence and the Road to Drug Resistance

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Microbial Persistence and the Road to Drug Resistance Nadia R. Cohen, Michael A. Lobritz, James J. Collins Cell Host & Microbe Volume 13, Issue 6, Pages 632-642 (June 2013) DOI: 10.1016/j.chom.2013.05.009 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Drug Persistence and Recurrent Infection Schematic model of killing and persistence kinetics during antimicrobial therapy. Treatment of an initial population of pathogens (I) causes killing of the majority of cells (II) but fails to eradicate a small subset of persisters (III). When antibiotic pressure is removed, persisters resume growth, resulting in recurrent infection of the host (IV). Retreatment results in similar killing kinetics. Cell Host & Microbe 2013 13, 632-642DOI: (10.1016/j.chom.2013.05.009) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Stress Responses Link Persistence, Adaptive Evolution, and Resistance In this model, microbial responses to endogenous or exogenous stresses promote survival as well as genetic plasticity. Persistent organisms undergo rapid adaptive evolution and can function as a reservoir for the elaboration of drug resistance. Cell Host & Microbe 2013 13, 632-642DOI: (10.1016/j.chom.2013.05.009) Copyright © 2013 Elsevier Inc. Terms and Conditions