The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery Ian J. Welsby, MBBS, Marla Troughton, MD, Barbara.

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Presentation transcript:

The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery Ian J. Welsby, MBBS, Marla Troughton, MD, Barbara Phillips-Bute, PhD, Rebecca Ramsey, MS, Mary Lee Campbell, MT(ASCP)SBB, Nicholas Bandarenko, MD, Joseph P. Mathew, MD, Mark Stafford-Smith, MD The Journal of Thoracic and Cardiovascular Surgery Volume 140, Issue 6, Pages 1353-1360 (December 2010) DOI: 10.1016/j.jtcvs.2009.12.035 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Postoperative pulmonary dysfunction rates in matched patients undergoing aortocoronary bypass surgery grouped by contributing types of complications (A) and the number of units they received (B) (1, 2, or >2 units) reflect an excess of pulmonary complications in equivalent recipients of male relative to female donor plasma. Major complications (30-day mortality or hospitalization >10 days) are also more common in equivalent recipients of male relative to female donor plasma (C). The Journal of Thoracic and Cardiovascular Surgery 2010 140, 1353-1360DOI: (10.1016/j.jtcvs.2009.12.035) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Kaplan–Meier estimates of survival in recipients of female compared with male donor plasma, log-rank test P = .09. Hazard ratio for female donor plasma, as estimated by the Cox proportional hazards model, adjusted for Hannan score, gender, weight, ethnicity (Caucasian vs non-Caucasian), previous stroke, and preoperative heparin therapy is 0.90; 95% confidence interval, 0.67–1.20; P = .47. The Journal of Thoracic and Cardiovascular Surgery 2010 140, 1353-1360DOI: (10.1016/j.jtcvs.2009.12.035) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions