Stefan Frank, Heiko Kämpfer, Christian Wetzler, Josef Pfeilschifter

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Nitric oxide drives skin repair: Novel functions of an established mediator Stefan Frank, Heiko Kämpfer, Christian Wetzler, Josef Pfeilschifter Kidney International Volume 61, Issue 3, Pages 882-888 (March 2002) DOI: 10.1046/j.1523-1755.2002.00237.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Intercellular communication network in a skin wound three days after injury. Protein-type growth factors are well established to orchestrate cell movements at the wound site. Abbreviations are: FGF, fibroblast growth factor; KGF, keratinocyte growth factor; PDGF, platelet-derived growth factor; TGF, transforming growth factor; VEGF, vascular endothelial growth factor. Kidney International 2002 61, 882-888DOI: (10.1046/j.1523-1755.2002.00237.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Nitric oxide (NO) as a signaling molecule at the wound site. The gaseous molecule NO serves as a mediator that regulates gene expression and proliferation in keratinocytes, and collagen synthesis in fibroblasts. Abbreviations are: NO, nitric oxide; MCP-1, macrophage chemoattractant protein-1; RANTES, regulated upon activation, normal T-cell expressed and secreted; VEGF, vascular endothelial growth factor. Kidney International 2002 61, 882-888DOI: (10.1046/j.1523-1755.2002.00237.x) Copyright © 2002 International Society of Nephrology Terms and Conditions