The Bare Lymphocyte Syndrome: Molecular Clues to the Transcriptional Regulation of Major Histocompatibility Complex Class II Genes Angela DeSandro, Uma.

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Presentation transcript:

The Bare Lymphocyte Syndrome: Molecular Clues to the Transcriptional Regulation of Major Histocompatibility Complex Class II Genes Angela DeSandro, Uma M. Nagarajan, Jeremy M. Boss The American Journal of Human Genetics Volume 65, Issue 2, Pages 279-286 (August 1999) DOI: 10.1086/302519 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Model of MHC class II gene regulation. Three stages of regulation are represented. The sequence-specific transcription factors that interact with the X1-, X2-, and Y-box elements assemble in all cells. Activation of gene expression occurs in two parts. The first is through the expression of CIITA and its interaction(s) with the DNA-bound factors. CIITA may interact with components of the general-transcription complex, including TATA-binding protein and its associated factors. The second part is provided by general coactivators of transcription (represented by CBP in this model) that augment activator-dependent transcription. Regulation of expression of MHC class II genes can occur at any of these steps, as depicted by the arrows and stops. The American Journal of Human Genetics 1999 65, 279-286DOI: (10.1086/302519) Copyright © 1999 The American Society of Human Genetics Terms and Conditions