Volume 155, Issue 2, Pages (February 2019)

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Volume 155, Issue 2, Pages 391-400 (February 2019) The Aging Lung Dawn M.E. Bowdish, PhD CHEST Volume 155, Issue 2, Pages 391-400 (February 2019) DOI: 10.1016/j.chest.2018.09.003 Copyright © 2018 American College of Chest Physicians Terms and Conditions

Figure 1 Changes in the aging lung. With age, physiologic changes such as airspace enlargement and decreased elasticity of the alveoli collectively contribute to reduced forced and end-expiratory lung volume. Concurrently, increased cellular senescence of fibroblasts and epithelial cells results in reduced resilience to injury and predisposes to fibrotic scarring. Age-associated inflammation includes elevated levels of inflammatory mediators and cytokines (soluble inflammation), as well as increased numbers of immune cells such as neutrophils, even in the absence of infection (cellular inflammation). Resident immune cells such as macrophages are less effective at resolving infections and may contribute to lung remodeling. CHEST 2019 155, 391-400DOI: (10.1016/j.chest.2018.09.003) Copyright © 2018 American College of Chest Physicians Terms and Conditions