M. Iwata, S. Inoue, M. Kawaguchi, H. Furuya

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Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance M. Iwata, S. Inoue, M. Kawaguchi, H. Furuya British Journal of Anaesthesia Volume 109, Issue 6, Pages 935-942 (December 2012) DOI: 10.1093/bja/aes340 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Experimental protocol. BCAO, bilateral carotid artery occlusion. British Journal of Anaesthesia 2012 109, 935-942DOI: (10.1093/bja/aes340) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 The percentage of injured neurones in the hippocampus and changes in body temperature in Experiments 1A and 1B in benzodiazepine-tolerant or naive (vehicle-treated) rats before BCAO. British Journal of Anaesthesia 2012 109, 935-942DOI: (10.1093/bja/aes340) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 The percentage of injured neurones in the hippocampus and changes in body temperature in Experiments 3–5. Experiment 3: benzodiazepine/vehicle: vehicle administered after BCAO in benzodiazepine-tolerant rats. Benzodiazepine/diazepam: diazepam administered after BCAO in benzodiazepine-tolerant rats. Vehicle/vehicle: vehicle administered after BCAO in benzodiazepine-naive rats. Vehicle/diazepam: diazepam administered after BCAO in benzodiazepine-naive rats. Experiment 4: benzodiazepine/vehicle: vehicle administered before BCAO in benzodiazepine-tolerant rats. Benzodiazepine/flumazenil: flumazenil administered before BCAO in benzodiazepine-tolerant rats. Vehicle/vehicle: vehicle administered before BCAO in benzodiazepine-naive rats. Vehicle/flumazenil: vehicle administered before BCAO in benzodiazepine-naive rats. Experiment 5: benzodiazepine/vehicle/diazepam: vehicle administered before BCAO and diazepam given after BCAO in benzodiazepine-tolerant rats. Benzodiazepine/flumazenil/diazepam: flumazenil administered before BCAO and diazepam given after BCAO in benzodiazepine-tolerant rats. Vehicle/vehicle/diazepam: vehicle administered before BCAO and diazepam given after BCAO in benzodiazepine-naive rats. Vehicle/flumazenil/diazepam: vehicle administered before BCAO and diazepam given after BCAO in benzodiazepine-naive rats. Pre, during, post-ischaemia: just before, during, and just after BCAO, respectively. 10 min, 1, 2, 3, 4 h, at 10 min and 1, 2, 3, and 4 h after BCAO, respectively. British Journal of Anaesthesia 2012 109, 935-942DOI: (10.1093/bja/aes340) Copyright © 2012 The Author(s) Terms and Conditions