Malignant hyperthermia: pharmacology of triggering

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Malignant hyperthermia: pharmacology of triggering P.M. Hopkins British Journal of Anaesthesia Volume 107, Issue 1, Pages 48-56 (July 2011) DOI: 10.1093/bja/aer132 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Box and whisker plot of the time from induction of anaesthesia to the onset of MH in 73 patients (eight received enflurane, 11 halothane, 42 isoflurane and 12 sevoflurane). The boxes delineate the inter-quartile range, the white horizontal line within the box is the median value, and the whiskers indicate the range. Using a general linear regression model, there was a statistically significant faster onset of the MH reaction with halothane vs enflurane and sevoflurane but not isoflurane. British Journal of Anaesthesia 2011 107, 48-56DOI: (10.1093/bja/aer132) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 A trace showing muscle tension in a skeletal muscle (Vastus medialis) specimen biopsied from a MH-susceptible patient. The test is a static halothane contracture test conducted according to the protocol of the European Makignant Hyperthermia Group (www.emhg.org) with an additional concentration of halothane (4% v/v) applied. The trace demonstrates the dose-dependent response of MH muscle in this system. British Journal of Anaesthesia 2011 107, 48-56DOI: (10.1093/bja/aer132) Copyright © 2011 The Author(s) Terms and Conditions