Coronary Microvascular Reactivity After Ischemic Cold Storage and Reperfusion Charles O Murphy, MD, Pan- Chih, MD, John Parker Gott, MD, Robert A Guyton,

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Presentation transcript:

Coronary Microvascular Reactivity After Ischemic Cold Storage and Reperfusion Charles O Murphy, MD, Pan- Chih, MD, John Parker Gott, MD, Robert A Guyton, MD The Annals of Thoracic Surgery Volume 63, Issue 1, Pages 20-27 (January 1997) DOI: 10.1016/S0003-4975(96)00767-9

Fig. 1 Responses to acetylcholine in vitro of canine coronary microvessels from the right ventricle in control hearts (CON; n = 10) and in hearts after 3 hours of cold ischemic storage using crystalloid cardioplegia (CCP; n = 8), Roe’s solution (ROE; n = 8), or University of Wisconsin solution (UW; n = 8) followed by 1 hour of reperfusion. Microvessels were pressurized (20 mm Hg) in a no-flow state and preconstricted with endothelin I by 30% to 40% of the baseline diameter. (SEM = standard error of the mean; ∗p < 0.05 compared with control.) The Annals of Thoracic Surgery 1997 63, 20-27DOI: (10.1016/S0003-4975(96)00767-9)

Fig. 2 Maximum response to calcium ionophore at a maximum concentration of 3 × 10−5 mol/L in vitro of canine coronary microvessels from the right ventricle in control hearts (CON; n = 10) and in hearts after 3 hours of cold ischemic storage using crystalloid cardioplegia (CCP; n = 8), Roe’s solution (ROE; n = 8), or University of Wisconsin solution (UW; n = 8) followed by 1 hour of reperfusion. (∗p < 0.05 compared with control.) The Annals of Thoracic Surgery 1997 63, 20-27DOI: (10.1016/S0003-4975(96)00767-9)

Fig. 3 Maximum response to acetylcholine at a maximum concentration of 3 × 10−5 mol/L in vitro of canine coronary microvessels from the left ventricle in control hearts (CON; n = 10) and in hearts after 3 hours of cold ischemic storage using crystalloid cardioplegia (CCP; n = 8), Roe’s solution (ROE; n = 8), or University of Wisconsin solution (UW; n = 8) followed by 1 hour of reperfusion. (∗p < 0.05 compared with control.) The Annals of Thoracic Surgery 1997 63, 20-27DOI: (10.1016/S0003-4975(96)00767-9)

Fig. 4 Maximum response to calcium ionophore at a maximum concentration of 3 × 10−5 mol/L in vitro of canine coronary microvessels from the left ventricle in control hearts (CON; n = 10) and in hearts after 3 hours of cold ischemic storage using crystalloid cardioplegia (CCP; n = 8), Roe’s solution (ROE; n = 8), or University of Wisconsin solution (UW; n = 8) followed by 1 hour of reperfusion. (∗p < 0.05 compared with control.) The Annals of Thoracic Surgery 1997 63, 20-27DOI: (10.1016/S0003-4975(96)00767-9)

Fig. 5 Maximum response to acetylcholine at a maximum concentration of 3 × 10−5 mol/L in vitro of canine coronary microvessels from the right ventricle (RV) in all groups (n = 24) and the left ventricle (LV) in all groups (n = 24) after 3 hours of cold ischemic storage followed by 1 hour of reperfusion. (∗p < 0.05 compared with combined left ventricular groups.) The Annals of Thoracic Surgery 1997 63, 20-27DOI: (10.1016/S0003-4975(96)00767-9)

Fig. 6 Maximum response to calcium ionophore at a maximum concentration of 3 × 10−5 mol/L in vitro of canine coronary microvessels from the right ventricle (RV) in all groups (n = 24) and the left ventricle (LV) in all groups (n = 24) after 3 hours of cold ischemic storage followed by 1 hour of reperfusion. (∗p < 0.05 compared with combined left ventricular groups.) The Annals of Thoracic Surgery 1997 63, 20-27DOI: (10.1016/S0003-4975(96)00767-9)