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Volume 65, Issue 4, Pages 1214-1223 (April 2004) Overexpression of complement inhibitor Crry does not prevent cryoglobulin-associated membranoproliferative glomerulonephritis Anja S. Mühlfeld, Stephan Segerer, Kelly Hudkins, Andrew G. Farr, Lihua Bao, Damian Kraus, V. Michael Holers, Richard J. Quigg, Charles E. Alpers Kidney International Volume 65, Issue 4, Pages 1214-1223 (April 2004) DOI: 10.1111/j.1523-1755.2004.00495.x Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 1 Glomerular morphology. Glomerular morphology in individual experimental groups, periodic-acid methenamine silver stain. Normal glomerular architecture in (A) a wild-type mouse and (B) a Crry transgenic mouse. (C) Mesangial expansion and matrix accumulation in a thymic stromal lymphopoietin (TSLP) transgenic mouse, and (D) a doubly (TSLP and Crry) transgenic mouse, with a glomerulus showing increase in extracellular matrix. Kidney International 2004 65, 1214-1223DOI: (10.1111/j.1523-1755.2004.00495.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 2 α-smooth muscle actin expression. Semiquantitative assessment of glomerular α-smooth muscle actin expression. Graphs depict mean ± standard deviation, with statistical significant differences between groups marked as *P < 0.05 and **P < 0.01. Kidney International 2004 65, 1214-1223DOI: (10.1111/j.1523-1755.2004.00495.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 3 Immunohistochemistry for macrophages. Macrophage immunohistochemistry using MAC-2 antibody, methyl green counterstain. Normal glomerulus of a (A) wild-type mouse and of a (B) Crry transgenic animal. (C) Mice transgenic for thymic stromal lymphopoietin (TSLP) have prominent glomerular macrophage influx, as do mice transgenic for TSLP and Crry, as illustrated in (D). Kidney International 2004 65, 1214-1223DOI: (10.1111/j.1523-1755.2004.00495.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 4 Plasma C3 levels. Plasma levels of C3 were measured by enzyme-linked immunosorbent assay (ELISA) in female and male animals. Data is presented as mean ± standard deviation. No statistically significant differences were observed. Kidney International 2004 65, 1214-1223DOI: (10.1111/j.1523-1755.2004.00495.x) Copyright © 2004 International Society of Nephrology Terms and Conditions

Figure 5 Immunoglobulins and complement. Semiquantitative assessment of glomerular immunoglobulin and complement deposition. Graphs show mean ± standard deviation, with statistical significant differences between groups expressed as *P < 0.05 and **P < 0.01. Kidney International 2004 65, 1214-1223DOI: (10.1111/j.1523-1755.2004.00495.x) Copyright © 2004 International Society of Nephrology Terms and Conditions