A Common Variation in EDAR Is a Genetic Determinant of Shovel-Shaped Incisors Ryosuke Kimura, Tetsutaro Yamaguchi, Mayako Takeda, Osamu Kondo, Takashi.

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A Common Variation in EDAR Is a Genetic Determinant of Shovel-Shaped Incisors Ryosuke Kimura, Tetsutaro Yamaguchi, Mayako Takeda, Osamu Kondo, Takashi Toma, Kuniaki Haneji, Tsunehiko Hanihara, Hirotaka Matsukusa, Shoji Kawamura, Koutaro Maki, Motoki Osawa, Hajime Ishida, Hiroki Oota The American Journal of Human Genetics Volume 85, Issue 4, Pages 528-535 (October 2009) DOI: 10.1016/j.ajhg.2009.09.006 Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 1 Evaluation of the Dental Morphology (A) Plaster casts of upper and lower teeth. The following abbreviations are used: U, upper; L, lower; I, incisor; C, canine; P, premolar; and M, molar. (B–D) Variation in shoveling, which refers to the development of marginal ridges on the lingual surfaces of UI1. (B) shows grade 1, (C) shows grade 3, and (D) shows grade 5. (E–G) Variation in double shoveling, which refers to the development of marginal ridges on the labial surfaces of UI1 (E) grade 1, (F) grade 3, and (G) grade 5. Arrows indicate pronounced mesial marginal ridges. The American Journal of Human Genetics 2009 85, 528-535DOI: (10.1016/j.ajhg.2009.09.006) Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 2 Locations and Allele Frequencies Pie charts indicate the allele frequencies for EDAR 1540T (white) and 1540C (black). The American Journal of Human Genetics 2009 85, 528-535DOI: (10.1016/j.ajhg.2009.09.006) Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 3 Eigenvectors in Principal Components The following abbreviations are used: U, upper; L, lower; I, incisor; C, canine; P, premolar; M, molar; BL, buccolingual diameter; and MD, mesiodistal diameter. The American Journal of Human Genetics 2009 85, 528-535DOI: (10.1016/j.ajhg.2009.09.006) Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 4 Distribution of Shoveling and Double-Shoveling Grades in Each Genotype The white bar indicates TT, the gray bar indicates CT, and the black bar indicates CC. The American Journal of Human Genetics 2009 85, 528-535DOI: (10.1016/j.ajhg.2009.09.006) Copyright © 2009 The American Society of Human Genetics Terms and Conditions

Figure 5 EDAR T1540C Genotypes and Principal Components The box plots depict minimum, lower quartile (Q1), median (Q2), upper quartile (Q3), maximum, and, if any, outliers for each genotype. The American Journal of Human Genetics 2009 85, 528-535DOI: (10.1016/j.ajhg.2009.09.006) Copyright © 2009 The American Society of Human Genetics Terms and Conditions