Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration J.P.H.J. Rutges, O.P. Jagt van der, F.C. Oner, A.J. Verbout,

Slides:

Advertisements

Similar presentations

Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory.

Advertisements

Efficacy of ultrasound therapy for the management of knee osteoarthritis: a systematic review with meta-analysis A. Loyola-Sánchez, J. Richardson, N.J.

Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study T.S. de Windt, L.A.

J. F. Bailey, A. J. Fields, E. Liebenberg, J. A. Mattison, J. C

Single-stage cell-based cartilage repair in a rabbit model: cell tracking and in vivo chondrogenesis of human umbilical cord blood-derived mesenchymal.

S. E. Gullbrand, N. R. Malhotra, T. P. Schaer, Z. Zawacki, J. T

T. Maerz, M. D. Newton, K. Kristof, O. Motovylyak, J. S. Fischgrund, D

Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT T.M. Piscaer, M. Sandker, O.P. van der.

One-stage focal cartilage defect treatment with bone marrow mononuclear cells and chondrocytes leads to better macroscopic cartilage regeneration compared.

The epidemiology and impact of pain in osteoarthritis

Validity and sensitivity to change of three scales for the radiographic assessment of knee osteoarthritis using images from the Multicenter Osteoarthritis.

Cartilage degeneration in the goat knee caused by treating localized cartilage defects with metal implants R.J.H. Custers, W.J.A. Dhert, D.B.F. Saris,

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

P.-S. Hsu, H.-H. Lin, C.-R. Li, W.-S. Chung

CT arthrography of the human knee to quantitatively measure cartilage biochemical composition: preliminary results of an in-vivo validation study using.

Y. H. Sniekers, G. J. V. M. van Osch, A. G. H. Ederveen, J. Inzunza, J

B.J. Ahern, J. Parvizi, R. Boston, T.P. Schaer

Parathyroid hormone [1-34] improves articular cartilage surface architecture and integration and subchondral bone reconstitution in osteochondral defects.

B.J. Ahern, J. Parvizi, R. Boston, T.P. Schaer

Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect.

Osteoarthritis as a disease of mechanics

Osteoarthritis and Cartilage

Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis

Osteoarthritis year 2011 in review: biochemical markers of osteoarthritis: an overview of research and initiatives Y. Henrotin Osteoarthritis and Cartilage

Prevention and treatment of intervertebral disc degeneration with bone marrow derived stem (stromal) cells – an in vivo study in sheep C.C. Shu, A. Dart,

J. P. H. J. Rutges, R. A. Duit, J. A. Kummer, F. C. Oner, M. H

Osteoarthritis and Cartilage

Validation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for the treatment of focal cartilage lesions J.E.J. Bekkers, Th.S. de Windt, N.J.H.

Demineralized bone matrix and platelet-rich plasma do not improve healing of osteochondral defects of the talus: an experimental goat study C.J.A. van.

Time to be positive about negative data?

Knee cartilage assessment with MRI (dGEMRIC) and subjective knee function in ACL injured copers: a cohort study with a 20 year follow-up P. Neuman, H.

Joint distraction attenuates osteoarthritis by reducing secondary inflammation, cartilage degeneration and subchondral bone aberrant change Y. Chen,

Real-time assessment of bone metabolism in small animal models for osteoarthritis using multi pinhole-SPECT/CT T.M. Piscaer, M. Sandker, O.P. van der.

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

Relationships between in vivo dynamic knee joint loading, static alignment and tibial subchondral bone microarchitecture in end-stage knee osteoarthritis

N.D. Miljkovic, M.D., Ph.D., G.M. Cooper, Ph.D., K.G. Marra, Ph.D.

J. Ranstam Osteoarthritis and Cartilage

Psychological factors and their relation to osteoarthritis pain

Quality of scaffold fixation in a human cadaver knee model

In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model F. Intema, H.A.W.

The role of subchondral bone, and its histomorphology, on the dynamic viscoelasticity of cartilage, bone and osteochondral cores N.L.A. Fell, B.M. Lawless,

Joint loading and proximal tibia subchondral trabecular bone microarchitecture differ with walking gait patterns in end-stage knee osteoarthritis B.C.

Clinically important body weight gain following total hip arthroplasty: a cohort study with 5-year follow-up D.L. Riddle, J.A. Singh, W.S. Harmsen, C.D.

Ethics in musculoskeletal regenerative medicine; guidance in choosing the appropriate comparator in clinical trials T.S. de Windt, S.L. Niemansburg,

Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects R.J.H. Custers, M.D., W.J.A. Dhert, M.D., Ph.D.,

M.Y. Chan, J.R. Center, J.A. Eisman, T.V. Nguyen

Arthroscopic airbrush assisted cell implantation for cartilage repair in the knee: a controlled laboratory and human cadaveric study T.S. de Windt, L.A.

Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis M. Blagojevic, C. Jinks, A. Jeffery, K.P.

A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading H.E. Kloefkorn, B.Y. Jacobs,

Who should have a joint replacement? A plea for more ‘phronesis’

J. P. H. J. Rutges, R. A. Duit, J. A. Kummer, J. E. J. Bekkers, F. C

Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography N.J. Willett, T. Thote, M. Hart,

A pilot study of the reproducibility and validity of measuring knee subchondral bone density in the tibia D. Dore, BBiotech.(Hons.), C. Ding, M.D., G.

I.C. Olsen, T.K. Kvien, T. Uhlig Osteoarthritis and Cartilage

A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee T.J. Schnitzer, J.A. Marks Osteoarthritis.

D.J. Hunter Osteoarthritis and Cartilage

Pain trajectory groups in persons with, or at high risk of, knee osteoarthritis: findings from the Knee Clinical Assessment Study and the Osteoarthritis.

A.B. Lovati, A. Pozzi, M. Bongio, C. Recordati, G. Berzero, M. Moretti

Most patients gain weight in the 2 years after total knee arthroplasty: comparison to a healthy control group J.A. Zeni, L. Snyder-Mackler Osteoarthritis.

Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA- Quest): a psychometric study L. Busija, R. Buchbinder, R.H. Osborne Osteoarthritis.

Osteoarthritis year 2012 in review: biology

Knee cartilage defects in a sample of older adults: natural history, clinical significance and factors influencing change over 2.9 years J. Carnes, O.

Radiographic scoring methods in hand osteoarthritis – a systematic literature search and descriptive review A.W. Visser, P. Bøyesen, I.K. Haugen, J.W.

Location-specific hip joint space width for progression of hip osteoarthritis – Data from the Osteoarthritis Initiative C. Ratzlaff, C. Van Wyngaarden,

M. Hudelmaier, W. Wirth Osteoarthritis and Cartilage

Systematic review of the impact of osteoarthritis on health outcomes for comorbid disease in older people L. Parkinson, D.L. Waters, L. Franck Osteoarthritis.

Osteoarthritis year in review 2016: mechanics

Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles J. Malda,

M. Doherty, P. Dieppe Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Presentation transcript:

Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration J.P.H.J. Rutges, O.P. Jagt van der, F.C. Oner, A.J. Verbout, R.J.M. Castelein, J.A. Kummer, H. Weinans, L.B. Creemers, W.J.A. Dhert Osteoarthritis and Cartilage Volume 19, Issue 1, Pages 89-95 (January 2011) DOI: 10.1016/j.joca.2010.09.010 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Example of macroscopical appearance and micro-CT images of IVDs for each degeneration grade according to the Thompson score. Osteoarthritis and Cartilage 2011 19, 89-95DOI: (10.1016/j.joca.2010.09.010) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Schematic overview of study procedure: micro-CT, VOI selection, and segmentation. Osteoarthritis and Cartilage 2011 19, 89-95DOI: (10.1016/j.joca.2010.09.010) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 A: Bone volume fraction for endplate and vertebral VOIs for each degeneration grade. B: Difference in bone volume fraction between endplate and vertebral VOIs for each degeneration grade. Grade II, III and V IVDs showed a significantly higher BV/TV in the endplate VOIs compared to the grade I VOIs. Error bars represent 95% confidence intervals. Grade I: N=5, II: N=5, III: N=7, IV: N=6 and grade V: N=4. ∗P<0.05. Osteoarthritis and Cartilage 2011 19, 89-95DOI: (10.1016/j.joca.2010.09.010) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions