BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

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Presentation transcript:

BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons Tomasz Skorski Chemistry & Biology Volume 18, Issue 11, Pages 1352-1353 (November 2011) DOI: 10.1016/j.chembiol.2011.11.001 Copyright © 2011 Elsevier Ltd Terms and Conditions

Figure 1 Targeting the SH2-Kinase Domain Interface in BCR-ABL1 Cartoon diagram of the SH2-kinase domain interface underlining the critical role of Ile164 (I164). The 7c12 monobody interferes with the I164 to inhibit BCR-ABL1 kinase activity. Chemistry & Biology 2011 18, 1352-1353DOI: (10.1016/j.chembiol.2011.11.001) Copyright © 2011 Elsevier Ltd Terms and Conditions