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Volume 18, Issue 3, Pages 207-213 (June 2011) Molecular origin of Na+/Li+ exchanger: Evidence against the involvement of major cloned erythrocyte transporters Svetlana V. Koltsova, Yulia A. Trushina, Olga A. Akimova, Pavel Hamet, Sergei N. Orlov Pathophysiology Volume 18, Issue 3, Pages 207-213 (June 2011) DOI: 10.1016/j.pathophys.2010.12.001 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Effect of phloretin and amiloride on the rate of Na+ influx in human, rat and rabbit erythrocytes (A) and Na+/Li+ countertransport in rabbit erythrocytes (B). Means±S.E., obtained in experiments performed in triplicate, are shown. *, ** – p<0.02 and 0.001, respectively, compared to the controls. Pathophysiology 2011 18, 207-213DOI: (10.1016/j.pathophys.2010.12.001) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Rate of Na+,Pi cotransport (A, B) and Na+/Li+ countertransport (C) in control (A) and Li+-loaded (B, C) human, rat and rabbit erythrocytes pre-incubated for 3h in medium C (A) or in medium B containing 140mM LiCl (B, C). For complete medium compositions, see Section 2. NLCT activity in rabbit erythrocytes was taken as 100%. Means±S.E. are shown. Pathophysiology 2011 18, 207-213DOI: (10.1016/j.pathophys.2010.12.001) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Composite 2DE maps of proteins extracted from erythrocyte ghosts. Proteins detected in erythrocytes from humans, rats and rabbits are presented in blue; proteins detected only in humans and rabbits appear in red. Proteins whose density is least 5-fold higher in rabbits than in humans are shown by extra black rings. Pathophysiology 2011 18, 207-213DOI: (10.1016/j.pathophys.2010.12.001) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions