Shifted from Wnt to Hedgehog Signaling Pathways

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Shifted from Wnt to Hedgehog Signaling Pathways Chun Han, Xinhua Lin Molecular Cell Volume 17, Issue 3, Pages 321-322 (February 2005) DOI: 10.1016/j.molcel.2005.01.009

Figure 1 Common Domain Structure and Distinct Functions of Human WIF-1 and Drosophila Shifted (A) Domain structure of human WIF-1 (hWIF-1) and Shifted. Both proteins contain a signal sequence (SS), WIF domain (WD), and five EGF-like repeats. WD of hWIF-1 is sufficient for its function, whereas both WD and EGF-like repeats are essential for the activity of Shifted. (B) hWIF-1 antagonizes Wnt signaling by preventing Wnt from binding to its receptors, Frizzled (Fz) and LRP5/6. (C) Shifted stabilizes Hh possibly by enhancing Hh/heparan sulfate proteoglycan (HSPG) interaction. Molecular Cell 2005 17, 321-322DOI: (10.1016/j.molcel.2005.01.009)