Salmonella’s Masterful Skill in Mast Cell Suppression

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Presentation transcript:

Salmonella’s Masterful Skill in Mast Cell Suppression Toshiaki Kawakami, Tomoaki Ando Immunity Volume 39, Issue 6, Pages 996-998 (December 2013) DOI: 10.1016/j.immuni.2013.11.007 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 S. Typhimurium Suppresses Mast Cell Degranulation by the Protein Tyrosine Phosphatase SptP (Left) WT S. Typhimurium-encoding SptP invades the host intestine and suppresses mast cell degranulation by T3SS-mediated injection of SptP, which targets Syk and NSF. Suppressed mast cell activation entails reduced recruitment of neutrophils to combat the bacteria, leading to severe infection. (Right) However, upon infection with ΔsptP S. Typhimurium, mast cells release granule-associated effectors, some of which recruit neutrophils to contain the bacteria to localized areas. YopH-containing Y. pestis can suppress mast cell activation similarly to WT S. Typhimurium, whereas E. coli allows mast cell degranulation (not shown). LN, lymph node. Immunity 2013 39, 996-998DOI: (10.1016/j.immuni.2013.11.007) Copyright © 2013 Elsevier Inc. Terms and Conditions