Inderpal S. Sarkaria, MD, Maureen F

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Epidermal Growth Factor Receptor Signaling in Adenocarcinomas With Bronchioloalveolar Components Inderpal S. Sarkaria, MD, Maureen F. Zakowski, MD, Duykhanh Pham, MD, Michael Hezel, BA, Michael I. Ebright, MD, Shaokun Chuai, MA, Ennapadam S. Venkatraman, PhD, Mark G. Kris, MD, Valerie W. Rusch, MD, Bhuvanesh Singh, MD The Annals of Thoracic Surgery Volume 85, Issue 1, Pages 216-223 (January 2008) DOI: 10.1016/j.athoracsur.2007.07.046 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Representative examples of marker expression in tumor cohort. (EGFR = epidermal growth factor receptor; p-AKT = phosphorylated murine thymoma viral oncogene homolog; PTEN = phosphatase and tensin homolog; p-ERK = phosphorylated extracellular signal related kinase.) The Annals of Thoracic Surgery 2008 85, 216-223DOI: (10.1016/j.athoracsur.2007.07.046) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 (A) Multidimensional scaling of study markers in bronchioloalveolar carcinoma. (B) Simplified schematic of known epidermal growth factor receptor (EGFR) signaling through phosphatidylinositol 3′ kinase (PI3K)-dependent and ras-dependent pathways. The Annals of Thoracic Surgery 2008 85, 216-223DOI: (10.1016/j.athoracsur.2007.07.046) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Overall survival and disease-free interval analyses by epidermal growth factor receptor status. The cumulative number of patients at risk (N at Risk) by year is represented by positive (pos) and negative (neg) immunophenotype status. Crosshatch marks represent censured data points. (A, B) OS and DFI for all tumors (median follow-up 73.0 and 31.5 months, respectively); (C, D) OS and DFI for BAC (median follow-up 49.1 and 25.7 months, respectively); (E, F) OS and DFI for adeno/BAC (median follow-up 81.5 and 45.3 months, respectively). (OS = overall survival; DFI = disease free interval; EGFR = epidermal growth factor receptor; BAC = bronchioloalveolar carcinoma; adeno/BAC = adenocarcinoma, mixed subtype, with bronchioloalveolar components.) The Annals of Thoracic Surgery 2008 85, 216-223DOI: (10.1016/j.athoracsur.2007.07.046) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions