Clinical Gastroenterology and Hepatology Surgical Fundoplication in Laryngopharyngeal Reflux Unresponsive to Aggressive Acid Suppression: A Controlled Study  Jason Swoger, Jeff Ponsky, Douglas M. Hicks, Joel E. Richter, Tom I. Abelson, Claudio Milstein, Mohammed A. Qadeer, Michael F. Vaezi  Clinical Gastroenterology and Hepatology  Volume 4, Issue 4, (April 2006) DOI: 10.1016/j.cgh.2006.01.011 Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 1 Study protocol. Clinical Gastroenterology and Hepatology 2006 4, DOI: (10.1016/j.cgh.2006.01.011) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 2 Esophageal acid exposure at baseline, after twice-daily PPI therapy, and at 3 and 12 months after fundoplication. Eight of 10 (80%) patients had abnormal esophageal acid exposure by pH monitoring at baseline that was normalized on PPI therapy and postfundoplication despite persistent symptoms. Clinical Gastroenterology and Hepatology 2006 4, DOI: (10.1016/j.cgh.2006.01.011) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

Figure 3 Symptom improvement after fundoplication compared with continued PPI therapy. Clinical Gastroenterology and Hepatology 2006 4, DOI: (10.1016/j.cgh.2006.01.011) Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions