A–c) This lung biopsy from a 55-year-old male patient, who was a nonsmoker, shows a typical desquamative interstitial pneumonia pattern. a–c) This lung.

Slides:

Advertisements

Similar presentations

Date of download: 9/17/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Demystifying Idiopathic Interstitial Pneumonia Arch.

Advertisements

Kaplan–Meier survival curves of interstitial pneumonia with autoimmune features (IPAF) with usual interstitial pneumonia (UIP) pattern (on high-resolution.

Pathological alterations in idiopathic pulmonary fibrosis (IPF).

a-d) Typical changes over time in different diffuse lung diseases

Longitudinal imaging after initial diagnosis

High-resolution computed tomography (HRCT) features of interstitial lung abnormalities. a) HRCT of a 56-year-old patient whose mother died of idiopathic.

Radiology assessment of pulmonary amyloidosis

Representative images of immunohistochemical staining of discoidin domain receptor (DDR)2 in interstitial lung disease (ILD) other than idiopathic pulmonary.

In chronic haemorrhage a) several pigmented macrophages fill the alveoli with dense fibrosis of the interstitium; b) the haemosiderin pigment in macrophages.

A) Chest radiograph, b) multislice computed tomography angiography, c) three-dimensional magnetic resonance angiography, d) perfusion scintigraphy and.

Alveolar lymphangiogenesis is a feature of idiopathic pulmonary fibrosis (IPF). a) Tissue sections reacted with anti-D2-40 (brown) and anti-CD34 (red)

Histopathological phenotypes in the lung allograft

High-resolution computed tomography scan revealing a nonspecific interstitial pneumonia pattern with basal predominant ground-glass opacities and associated.

a) Chest radiograph showing bilateral coarse interstitial shadowing

Nonspecific interstitial pneumonia in a woman a, c) at the time of Sjögren's syndrome diagnosis and b) after 3 years. a, b) High-resolution computed tomography.

A) Usual interstitial pneumonia in a 69-year-old woman with primary Sjögren's syndrome. a) Usual interstitial pneumonia in a 69-year-old woman with primary.

Examples of distal lung disease in “atypical” severe asthma and differential diagnoses from video-assisted thoracoscopic surgery procured tissue. a) Small.

Representative photomicrograph of small airways abnormalities in a subject with chronic obstructive pulmonary disease. Representative photomicrograph of.

A) Low magnification histopathological biopsy showing typical features of usual interstitial pneumonia pattern with a heterogeneous appearance and areas.

Extent of interstitial lung disease (ILD) in patients with systemic sclerosis-associated ILD. A simple stratification that utilises pulmonary function.

Computed tomography coronary angiogram from a 43-year-old female patient with pulmonary arterial hypertension, showing compression of the left coronary.

A 45-year-old smoking man diagnosed with desquamative interstitial pneumonia (DIP) by a) cryo-transbronchial lung biopsy (haematoxylin–eosin stain) showing.

Radiological evolution of acute respiratory distress syndrome over the first week in a 57-year-old male with non-Hodgkin’s lymphoma and H1N1 infection.

Representative photomicrographs of individual bronchiolar lesions observed in surgical lung biopsy in patients with small airways disease. a) Cellular.

Nonspecific interstitial pneumonia: high-resolution computed tomography images from a 46-year-old male patient who underwent lung transplantation. a) The.

Nonspecific interstitial pneumonia fibrosing pattern in a case of connective tissue disease. a) The alveolar walls are thickened by interstitial fibrosis.

Radiodiagnostic imaging

3-year survival of lung cancer patients in the general population and in those with a prior diagnosis of chronic obstructive pulmonary disease (COPD).

Multiple (type 3) cyst-related primary lung malignancies presenting as cystic airspaces with asymmetrical or circumferential wall thickening. a, b) A 52-year-old.

Pattern high-resolution computed tomography consistent with nonspecific interstitial pneumonia in a patient with histological diagnosis of usual interstitial.

Evaluation of acute symptoms

A summary of the pathogenesis, pathophysiology and clinical implications of the pulmonary vascular and cardiac abnormalities in interstitial lung disease.

A) Respiratory bronchiolitis: the intra-alveolar accumulation of finely pigmented macrophages (smoker’s macrophages) (haematoxylin and eosin, 400×). a)

Cyst-related lung malignancies might be more common than expected, as the early manifestations of solid masses may not always be captured. a–c) Baseline.

Cumulative count of the different primary pulmonary function test (PFT) outcomes in longitudinal studies of systemic sclerosis-associated interstitial.

Time to disease progression or death in a) the whole Bosentan Use in Interstitial Lung Disease (BUILD)-1 study population and b) the subpopulation with.

Evaluation of complications.

Elastic staining of paraffin-embedded lung tissue.

A) 18-fluorodeoxyglucose positron emission tomography-computed tomography in a 72-year-old male revealed pulmonary nodules in the lower lobes. a) 18-fluorodeoxyglucose.

Simplified diagram of the multidisciplinary process to diagnose interstitial lung disease, including a clinician, radiologist, pathologist and also a geneticist:

Proteinase activated receptor-1 expression in a) weak immunostaining in normal lung tissue, b) intense immunostaining in idiopathic pulmonary fibrosis,

Morphological subtypes of cyst-related primary lung malignancies

High-resolution computed tomography scan of a 59-year-old female patient with undifferentiated connective tissue disease, showing patterns of nonspecific.

Endobronchial biopsy from case 2 showing sheets of epitheloid macrophages without giant cells, mixed with other chronic inflammatory cells. Endobronchial.

Outline of the distal lung regions in haematoxylin and eosin-stained lung tissue [115, 116] showing the inner airway wall (green arrowheads), smooth muscle.

Transbronchial cryobiopsy (TBCx)

A) The accumulation of haemosiderin pigment may be observed in some cases of pneumoconiosis, such as b) asbestosis with the presence of asbestos bodies.

A) The neoplastic cells have medium-to-large size, abundant cytoplasm and enlarged, irregular nuclei. b) Immunohistochemical stain for CD79a is positive,

Forest plot of the a) sensitivity and b) specificity of different pulmonary function test screening algorithms for the presence of systemic sclerosis-associated.

A–c) Case 1, with epidermal growth factor receptor (EGFR) exon 21 mutations (V843I and L858R). a) Pedigree chart. a–c) Case 1, with epidermal growth factor.

Example of thin parenchymal section computed tomography findings in desquamative interstitial pneumonia: patchy ground-glass attenuation with a peripheral.

Chronic hypersensitivity pneumonitis with usual interstitial pneumonia pattern. a) At low magnification, bronchiolar damage with bridging fibrosis between.

A) Small pulmonary arteries within a fibrotic area (usual interstitial pneumonia lung). a) Small pulmonary arteries within a fibrotic area (usual interstitial.

A) Axial and b) coronal computed tomography scans of usual interstitial pneumonia pattern in a patient with rheumatoid arthritis. a) Axial and b) coronal.

Usual interstitial pneumonia pattern in two patients with idiopathic pulmonary fibrosis. a) At low magnification, subpleural/paraseptal scars obscuring.

High-resolution computed tomography with nonspecific interstitial pneumonia pattern in a patient with connective tissue disease; bilateral reticulation.

Correlation between inspiratory capacity (IC)/total lung capacity (TLC) ratio and oxygen pulse at peak exercise in chronic obstructive pulmonary disease.

Clinical findings in patients with chronic obstructive pulmonary disease according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD)

Procedure for the diagnosis of interstitial lung diseases.

a) A 2-year-old male with Niemann–Pick disease type A

Progression in the patient’s pulmonary function tests from 2010 to a) Forced vital capacity (FVC); b) total lung capacity (TLC); c) diffusing capacity.

High-resolution computed tomography from a patient with anti-Jo1 positive polymyositis showing basilar predominate reticulation and ground-glass opacity.

Bronchial biopsy from patient 5 (a; Haematoxylin-Eosin-Safran stain and ×10 growth). Bronchial biopsy from patient 5 (a; Haematoxylin-Eosin-Safran stain.

Hyperplastic alveolar epithelial type II cells show severe endoplasmic reticulum stress and consecutive apoptosis. Hyperplastic alveolar epithelial type.

Open lung biopsy specimen showing an inflammation with thickened interalveolar septa and the inflammatory infiltration of mononuclear cells (areas of a.

High-resolution computed tomography scan demonstrating a typical example of usual interstitial pneumonia pattern with honeycombing change and traction.

A) Dyspnoea response at rest, iso-time, and peak exercise in 20 patients with fibrotic interstitial lung disease during constant work-rate cycle exercise.

Lung macrophage development and composition through the lifespan.

High-resolution computed tomography images of smoking-related interstitial lung diseases (ILDs). a) Pulmonary Langerhans cell histiocytosis, b) respiratory.

A) Smokers’ macrophages show a fine, golden haemosiderin cytoplasmic pigment; b) in respiratory bronchiolitis (RB), smokers’ macrophages are located in.

Presentation transcript:

a–c) This lung biopsy from a 55-year-old male patient, who was a nonsmoker, shows a typical desquamative interstitial pneumonia pattern. a–c) This lung biopsy from a 55-year-old male patient, who was a nonsmoker, shows a typical desquamative interstitial pneumonia pattern. Tissue sections show a) diffuse involvement of the lung by intense macrophage accumulations within almost all of the distal airspace, b) without significant thickening of alveolar septa and sparse inflammatory infiltrate (*). Macrophages do not contain dusty pigment. c) Immunohistochemical analysis with CD163 antibody shows the macrophage nature of the cells. d–f) Lung biopsy from a 66-year-old female, who was a heavy smoker, showing a respiratory bronchiolitis/interstitial lung disease pattern. d) Macrophage accumulation is diffuse but predominantly peribronchiolar and f) in respiratory bronchioles. Alveolar septa are slightly thickened. e) The cytoplasm of most macrophages contains an abundant dust-brown pigment. Benoît Godbert et al. Eur Respir Rev 2013;22:117-123 ©2013 by European Respiratory Society