Dopamine: Burning the Candle at Both Ends

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Dopamine: Burning the Candle at Both Ends John M. Pearson, Michael L. Platt Neuron Volume 79, Issue 5, Pages 831-833 (September 2013) DOI: 10.1016/j.neuron.2013.08.011 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Dopamine Neurons Respond to Events in a Working-Memory Task (A) Putative dopaminergic neurons in both SNc and VTA respond more strongly to cues predicting high-reward trials than to those predicting low-reward trials. (B) Cells in the dorsolateral SNc respond to the presentation of a visual stimulus when that stimulus must be maintained in working memory, but not when it is irrelevant to task performance. (C) Cells respond more strongly to the onset of smaller, easier search arrays than to larger, more difficult arrays. Responsive cells are more strongly concentrated in the medial SNc and VTA. (D) Cells respond more strongly to the location of a search target when that target is located in a larger (more difficult) array. More red indicates a stronger population response. All comparisons are relative within vertical columns. Neuron 2013 79, 831-833DOI: (10.1016/j.neuron.2013.08.011) Copyright © 2013 Elsevier Inc. Terms and Conditions