Aquaporin gene delivery to kidney

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Aquaporin gene delivery to kidney Alan S. Verkman, Baoxue Yang Kidney International Volume 61, Issue 1, Pages S120-S124 (January 2002) DOI: 10.1046/j.1523-1755.2002.0610s1120.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 Immunofluorescence localization of AQP1 protein in kidneys of adenovirus-treated AQP1 null mice. (A) AQP1 expression at four days after direct intrarenal injection. *, injection site. (B) Localization of AQP1 in cortex, and (C) medulla at four days after a single intravenous infusion of adenovirus. Scale bar, 100 μm. Kidney International 2002 61, S120-S124DOI: (10.1046/j.1523-1755.2002.0610s1120.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Urine osmolality and mouse weight loss in AQP1 null mice before vs. after virus infusion. (A) Urine osmolalities measured at indicated times before and after a 36-hour water deprivation. Water deprivation tests were done prior to and after virus treatment. (B) Body weight loss (expressed as percentage initial weight) in water deprivation tests done before and after virus treatment. *P < 0.05. (C) Increase in urine osmolalities (mean ± SE) for 36-hour water deprivation tests done at indicated times after virus treatment. Adapted from [32]. Kidney International 2002 61, S120-S124DOI: (10.1046/j.1523-1755.2002.0610s1120.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Summary of (A) urine osmolalities and (B) weight loss in a series of wild-type, untreated AQP1 knockout, and virus-treated AQP1 knockout mice. Virus-treated knockout mice were given 5-10 × 109 pfu adenovirus at three or four days prior to water deprivation test. Data (mean ± SE) are shown for 36-hour water deprivation tests. Numbers of mice in each group are shown in parentheses. * P < 0.05; ** P < 0.01 (Student t test). Adapted from [32]. Kidney International 2002 61, S120-S124DOI: (10.1046/j.1523-1755.2002.0610s1120.x) Copyright © 2002 International Society of Nephrology Terms and Conditions