Role of CD8+ cells in the progression of murine adriamycin nephropathy

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Role of CD8+ cells in the progression of murine adriamycin nephropathy Yang Wang, Yi Ping Wang, Yuet-Ching Tay, David C.H. Harris Kidney International Volume 59, Issue 3, Pages 941-949 (March 2001) DOI: 10.1046/j.1523-1755.2001.059003941.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 CD4+ and CD8+ cell levels as a percentage of the total splenocyte population at week 6. Symbols are: (?) normal; (□) adriamycin (ADR); (▪) ADR + anti-CD8. Values are expressed as mean ± SD. *P < 0.05 compared with other two groups. Kidney International 2001 59, 941-949DOI: (10.1046/j.1523-1755.2001.059003941.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Representative sections showing morphological changes as stained by PAS (A–C) and by Masson's trichrome (D–F). Magnification ×400. (A and D) Saline-treated control mice show normal glomeruli, tubules, and interstitium. (B and E) ADR-treated mice show glomerular sclerosis and vacuolization (B, arrowhead), tubular collapse and interstitial expansion (B, star), and numerous hyaline and cellular (B, arrow) casts at week 6. In addition, there is obvious interstitial fibrosis (E, arrowheads). (C and F) ADR mice treated with anti-CD8 show mild glomerular sclerosis and mild tubular dilation and atrophy at week 6, despite hyaline casts indicating proteinuria. However, interstitial cellular infiltration (C, arrowheads) is widespread, and the fissures between tubules (C, arrows) reveal the edema but not fibrosis in interstitium. There is also less collagen deposition in the interstitium (F) than that of mice treated with ADR only (E). Kidney International 2001 59, 941-949DOI: (10.1046/j.1523-1755.2001.059003941.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Photomicrographs of immunohistochemical (IHC) sections from saline-treated control mice (A), ADR-treated mice (B), and mice treated with ADR plus anti-CD8 (C). Sections are stained by antimouse Mac-3 mAb (macrophage). Magnification ×400. Kidney International 2001 59, 941-949DOI: (10.1046/j.1523-1755.2001.059003941.x) Copyright © 2001 International Society of Nephrology Terms and Conditions