ChEA, ChIP Enrichment Analysis.

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ChEA, ChIP Enrichment Analysis. Supplementary Figure 2. Example pilot in silico network meta-analysis of using gene sets*. (A) In silico analyses was conducted by using gene lists in AR and TOL genes. Each subpanel represents a result of Gene Ontology (GO) molecular function bioinformatics analysis. Each circle represents an enriched pathway associated with a gene-set library pathway. The annotated circles are overlapped enriched terms with both gene lists and colored in cyan blue. The lighter cyan blue, statistically more meaningful the circle is. Every annotated circle is statistically significant. The white or lighter cyan blue circles are under p-value 0.01 while gray or darker cyan blue circles are under p-value 0.05. (B) Each subpanel represents a result of PPI hub proteins analysis in AR and TOL genes. Each circle represents an enriched hub protein associated with each condition. The annotated cyan circles are shared enriched hub proteins in both conditions. Every annotated circle is statistically significant. White circles are under p-value 0.01 while gray circles are under p-value 0.05. The lighter cyan blue is under p-value 0.01 and the darker cyan blue is under p-value 0.05. (G) Examples of systems biology approaches of AR genes. In silico analyses was conducted by using different gene-set libraries. Each subpanel represents a result of distinct bioinformatics database library analysis. Each square represents a gene list associated with a gene-set library pathways or terms. The annotated circles are top 20 ranks enriched terms in each database library. They were visualized by Network2Canvas tools. ChEA, ChIP Enrichment Analysis. * DEGs of AR from Khatri et al. (5) and TOL from Baron et al. (6). Supplementary Figure 2. Example pilot in silico network meta-analysis of using gene sets*. (A) In silico analyses was conducted by using gene lists in AR and TOL genes. Each subpanel represents a result of Gene Ontology (GO) molecular function bioinformatics analysis. Each circle represents an… Immune Netw. 2017 Jan;17:e8.