Getting RNA and Protein in Phase

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Getting RNA and Protein in Phase Stephanie C. Weber, Clifford P. Brangwynne Cell Volume 149, Issue 6, Pages 1188-1191 (June 2012) DOI: 10.1016/j.cell.2012.05.022 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Intracellular Biomolecules Undergo Phase Transitions (A) Nonbiological molecules can exist in different phases: gas, with few intermolecular interactions; liquid, with many transient intermolecular interactions; and solid, with stable bonds. Transitions between these phases are driven by external parameters such as temperature. (B) The nucleus and cytoplasm appear to be organized by similar phase transitions. Multivalent interaction domains and low-complexity sequences drive soluble RNA and protein molecules to transiently associate with each other, forming liquid-like granules in the cell. ATP-dependent biological activity could enable the cell to dynamically control the assembly and disassembly of these phases. Intriguingly, structural characterization suggests that the same intermolecular interactions underlying granule assembly can lead to the formation of stable amyloid aggregates seen in diseases such as Alzheimer's. Cell 2012 149, 1188-1191DOI: (10.1016/j.cell.2012.05.022) Copyright © 2012 Elsevier Inc. Terms and Conditions