Hydrothermal Duodenal Mucosal Resurfacing

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Presentation transcript:

Hydrothermal Duodenal Mucosal Resurfacing Alan D. Cherrington, PhD, Harith Rajagopalan, MD, PhD, David Maggs, MD, Jacques Devière, MD, PhD Gastrointestinal Endoscopy Clinics Volume 27, Issue 2, Pages 299-311 (April 2017) DOI: 10.1016/j.giec.2016.12.002 Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 1 Oral glucose tolerance test (OGTT) results in the Goto-Kakizaki rat (n = 9) before and after duodenal abrasion. Duodenal abrasion was associated with a 25% improvement in area under the curve for OGTT. Gastrointestinal Endoscopy Clinics 2017 27, 299-311DOI: (10.1016/j.giec.2016.12.002) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 2 Revita DMR catheter. (A) First-generation, single-use balloon catheter used to perform hydrothermal ablation of the duodenal mucosa. (B) The balloon inflated in the duodenum during hydrothermal ablation. (Courtesy of Fractyl Laboratories, Inc, Lexington, MA; with permission.) Gastrointestinal Endoscopy Clinics 2017 27, 299-311DOI: (10.1016/j.giec.2016.12.002) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 3 The duodenal mucosa immediately after hydrothermal ablation. (Courtesy of Fractyl Laboratories, Inc, Lexington, MA; with permission.) Gastrointestinal Endoscopy Clinics 2017 27, 299-311DOI: (10.1016/j.giec.2016.12.002) Copyright © 2016 Elsevier Inc. Terms and Conditions

Fig. 4 Effect of DMR on HbA1c level and liver enzymes in the FIH cohort (most recent data capture of n = 48). Shaded area is ±1 standard error of the mean. (A) HbA1c levels at screening, 1, 3, and 6 months in subjects with preprocedure HbA1c levels of 7.5% to 10% and 3 or more ablations (n = 19). (B) Impact of DMR on alanine transaminase (ALT) by screening ALT level in subjects with 3 or more ablations (highest screening ALT, n = 15; lowest screening ALT, n = 15). Gastrointestinal Endoscopy Clinics 2017 27, 299-311DOI: (10.1016/j.giec.2016.12.002) Copyright © 2016 Elsevier Inc. Terms and Conditions