Need for Speed: Mechanical Regulation of a Replicative Helicase

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Need for Speed: Mechanical Regulation of a Replicative Helicase Taekjip Ha Cell Volume 129, Issue 7, Pages 1249-1250 (June 2007) DOI: 10.1016/j.cell.2007.06.007 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 How Helicases Speed Up (A) A hexameric helicase moves on the lagging strand in the 5′ to 3′ direction and unwinds the double-stranded DNA ahead. Its unwinding speed is much lower than its intrinsic translocation speed, possibly due to an inhibitory interaction between the helicase and the opposing strand. When a force is applied on the DNA strands (B) or when a DNA polymerase reaction is coupled with unwinding (C), the unwinding speed is dramatically enhanced. Therefore, regulation of helicase activities by other proteins may be mechanical in origin. Cell 2007 129, 1249-1250DOI: (10.1016/j.cell.2007.06.007) Copyright © 2007 Elsevier Inc. Terms and Conditions