The human norovirus genome.

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The human norovirus genome. The human norovirus genome. The genome is comprised of a linear, positive-sense RNA, ∼7.6 kb in length, covalently linked to the viral protein genome (VPg) (solid black circle) at the 5′ end and polyadenylated at the 3′ end. There are three open reading frames (ORFs), designated ORF-1, ORF-2, and ORF-3, encoding 8 viral proteins. ORF-1 encodes the 6 nonstructural (NS) proteins that are proteolytically processed by the virally encoded cysteine proteinase (Pro). ORF-2 and ORF-3 encode the structural components of the virion, viral protein 1 (VP1) and VP2, respectively. Elizabeth Robilotti et al. Clin. Microbiol. Rev. 2015; doi:10.1128/CMR.00075-14