Hydrophilic surface modification of metallic endoluminal stents

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Presentation transcript:

Hydrophilic surface modification of metallic endoluminal stents James M. Seeger, MD, Michael D. Ingegno, MD, Emmanuel Bigatan, MEng, Nina Klingman, BS, Drew Amery, BS, Chris Widenhouse, BS, Eugene P. Goldberg, PhD Journal of Vascular Surgery Volume 22, Issue 3, Pages 327-336 (September 1995) DOI: 10.1016/S0741-5214(95)70148-6 Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 X-ray photoelectron spectroscopy of plain stainless steel slab (top) and poly-NVP modified stainless steel slab (bottom). Increased nitrogen peak at 295 eV in bottom spectra demonstrates successful surface grafting of stainless steel surface with poly-NVP. Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 X-ray photoelectron spectroscopy of plain stainless steel slab (top) and poly-NVP modified stainless steel slab (bottom). Increased nitrogen peak at 295 eV in bottom spectra demonstrates successful surface grafting of stainless steel surface with poly-NVP. Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 High-resolution x-ray photoelectron spectroscopy of plain stainless steel slab (top) and poly-KSPA modified stainless steel slab (bottom). Increased sulfur peak at 169 eV in bottom spectra demonstrates successful surface grafting of stainless steel surface with poly-KSPA. Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 High-resolution x-ray photoelectron spectroscopy of plain stainless steel slab (top) and poly-KSPA modified stainless steel slab (bottom). Increased sulfur peak at 169 eV in bottom spectra demonstrates successful surface grafting of stainless steel surface with poly-KSPA. Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Scanning electron micrographs of plain (left) and hydrophilic surface modified (right) Palmaz stainless steel stents. In higher magnification studies (bottom), surface of plain stents can be seen to be very irregular, and some evidence of smoothing of irregular cut surface, which has undergone surface modification with hydrophilic polymer, can be seen. Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Scanning electron micrographs of plain (top), poly-KSPA modified (middle), and poly-NVP modified (bottom) Palmaz stainless steel stents after 1 hour of blood flow exposure in canine arteriovenous shunt. Significant platelet accumulation (small arrow) is seen on surface of plain stent (top), whereas red blood cells, white blood cells, and some fibrin (large arrows) but few platelets are seen on surface of modified stents (middle and bottom). Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Scanning electron micrographs of plain (top), poly-KSPA modified (middle), and poly-NVP modified (bottom) Palmaz stainless steel stents after 1 hour of blood flow exposure in canine arteriovenous shunt. Significant platelet accumulation (small arrow) is seen on surface of plain stent (top), whereas red blood cells, white blood cells, and some fibrin (large arrows) but few platelets are seen on surface of modified stents (middle and bottom). Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Scanning electron micrographs of plain (top), poly-KSPA modified (middle), and poly-NVP modified (bottom) Palmaz stainless steel stents after 1 hour of blood flow exposure in canine arteriovenous shunt. Significant platelet accumulation (small arrow) is seen on surface of plain stent (top), whereas red blood cells, white blood cells, and some fibrin (large arrows) but few platelets are seen on surface of modified stents (middle and bottom). Journal of Vascular Surgery 1995 22, 327-336DOI: (10.1016/S0741-5214(95)70148-6) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions