Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone.

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Presentation transcript:

Therapeutic angiogenesis in Buerger's disease (thromboangiitis obliterans) patients with critical limb ischemia by autologous transplantation of bone marrow mononuclear cells Vishnu Motukuru, MBBS, MS, DNB, Kalkunte R. Suresh, MBBS, DABS, Vivekanand Vivekanand, MBBS, MS, Sumanth Raj, MBBS, MS, K.R. Girija, MBBS Journal of Vascular Surgery Volume 48, Issue 6, Pages 53S-60S (December 2008) DOI: 10.1016/j.jvs.2008.09.005 Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 1 A grid was created over calf muscles and bone marrow mononuclear cells were injected in 30 to 40 sites. Journal of Vascular Surgery 2008 48, 53S-60SDOI: (10.1016/j.jvs.2008.09.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 2 Strongyloides stercoralis was found in the bone marrow aspirate of one patient. Journal of Vascular Surgery 2008 48, 53S-60SDOI: (10.1016/j.jvs.2008.09.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 3 This patient had severe hand ischemia with nonreconstructible thromboangiitis obliterans. Journal of Vascular Surgery 2008 48, 53S-60SDOI: (10.1016/j.jvs.2008.09.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 4 A, Toe amputation site after failed vascular reconstruction and B, 5 weeks after therapy. Journal of Vascular Surgery 2008 48, 53S-60SDOI: (10.1016/j.jvs.2008.09.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 5 A, Representation of the mean ankle-brachial index and standard error (bars). B, Representation of individual subject data for the ankle-brachial index. Journal of Vascular Surgery 2008 48, 53S-60SDOI: (10.1016/j.jvs.2008.09.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 6 A, Representation of visual analog scale data and standard error (bars). B, Representation of individual subject data on the visual analog scale. Journal of Vascular Surgery 2008 48, 53S-60SDOI: (10.1016/j.jvs.2008.09.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 7 A, Representation of mean transcutaneous oximetry data and the standard error (bars). B, Representation of individual subject data for transcutaneous oximetry levels. Journal of Vascular Surgery 2008 48, 53S-60SDOI: (10.1016/j.jvs.2008.09.005) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions