Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females1 1.

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Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females1 1 Sources of support: National Health and Medical Research Council of Australia, Masonic Centenary Medical Research Foundation. G Jones, M.D., Changhai Ding, M.D., F Scott, MBBS, M Glisson, M.App.Sci., F Cicuttini, Ph.D. Osteoarthritis and Cartilage Volume 12, Issue 2, Pages 169-174 (February 2004) DOI: 10.1016/j.joca.2003.08.010

Fig. 1 MRI assessment of cartilage volume and bone area. Cartilage volume (A) is manually outlined in an average of 60 sagittal cuts and then summed giving a volume estimate. For bone area, the three reformatted axial images closest to the knee are averaged to give areas for the medial and lateral tibial plateaux. Roi-1—lateral; Roi-2—medial. Osteoarthritis and Cartilage 2004 12, 169-174DOI: (10.1016/j.joca.2003.08.010)

Fig. 2 Increases in tibial area with early medial osteophytosis by sex. At all sites, there is an increase in tibial areas varying from 10–22% in unadjusted analyses. All results reached statistical significance. Results are presented as mean±SE. Osteoarthritis and Cartilage 2004 12, 169-174DOI: (10.1016/j.joca.2003.08.010)

Fig. 3 Reductions in cartilage volume with early joint space narrowing by sex. At all sites there is a reduction in cartilage volume varying from 7–15% in unadjusted analysis which reaches statistical significance in females only. Results are presented as mean±SE. Osteoarthritis and Cartilage 2004 12, 169-174DOI: (10.1016/j.joca.2003.08.010)