Role of therapeutic hypothermia in improving outcome after traumatic brain injury: a systematic review A.P. Georgiou, A.R. Manara British Journal of.

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Presentation transcript:

Role of therapeutic hypothermia in improving outcome after traumatic brain injury: a systematic review A.P. Georgiou, A.R. Manara British Journal of Anaesthesia Volume 110, Issue 3, Pages 357-367 (March 2013) DOI: 10.1093/bja/aes500 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 Flow diagram of literature search and retrieved results. British Journal of Anaesthesia 2013 110, 357-367DOI: (10.1093/bja/aes500) Copyright © 2013 The Author(s) Terms and Conditions

Fig 2 Forest plot of all included trials examining the effect of prophylactic therapeutic hypothermia vs normothermia on mortality in TBI. The estimate of heterogeneity places a numerical value on the variation in the results of individual studies, thereby suggesting the confidence that one can have in the combined estimate. The results from these studies are relatively heterogeneous. British Journal of Anaesthesia 2013 110, 357-367DOI: (10.1093/bja/aes500) Copyright © 2013 The Author(s) Terms and Conditions

Fig 3 Funnel plot of all included trials examining the effect of publication bias in trials reporting mortality outcomes of prophylactic therapeutic hypothermia vs normothermia in TBI. The y-axis represents a measure of the precision of the estimated treatment effect. Thus, smaller trials with wider confidence intervals will appear lower on the y-axis and increase the chance of the inverted funnel being non-symmetrical. Publication bias is a common explanation for a funnel plot being non-symmetrical. The symmetry of this plot suggests publication bias is unlikely. British Journal of Anaesthesia 2013 110, 357-367DOI: (10.1093/bja/aes500) Copyright © 2013 The Author(s) Terms and Conditions

Fig 4 Forest plot of only high-quality trials, examining the effect of prophylactic therapeutic hypothermia vs normothermia on mortality in TBI. The analysis of heterogeneity suggests that these studies are very homogeneous. British Journal of Anaesthesia 2013 110, 357-367DOI: (10.1093/bja/aes500) Copyright © 2013 The Author(s) Terms and Conditions

Fig 5 Forest plot of all included trials examining the effect of prophylactic therapeutic hypothermia vs normothermia on poor neurological outcome after TBI. The analysis of heterogeneity suggests that these studies are very heterogeneous. British Journal of Anaesthesia 2013 110, 357-367DOI: (10.1093/bja/aes500) Copyright © 2013 The Author(s) Terms and Conditions

Fig 6 Funnel plot of all included trials examining the effect of publication bias in trials reporting neurological outcomes of prophylactic therapeutic hypothermia vs normothermia in TBI. The symmetry of this plot suggests that publication bias is unlikely. British Journal of Anaesthesia 2013 110, 357-367DOI: (10.1093/bja/aes500) Copyright © 2013 The Author(s) Terms and Conditions

Fig 7 Forest plot of only high-quality trials, examining the effect of prophylactic therapeutic hypothermia vs normothermia on poor neurological outcome after TBI. The analysis of heterogeneity suggests these studies are very homogeneous. British Journal of Anaesthesia 2013 110, 357-367DOI: (10.1093/bja/aes500) Copyright © 2013 The Author(s) Terms and Conditions