Volume 86, Issue 5, Pages (November 2014)

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Volume 86, Issue 5, Pages 1057-1058 (November 2014) Sodium glucose cotransport-2 inhibition and intrarenal RAS activity in people with type 1 diabetes David Z.I. Cherney, Bruce A. Perkins, Nima Soleymanlou, Fengxia Xiao, Joseph Zimpelmann, Hans-Juergen Woerle, Odd E Johansen, Uli C. Broedl, Maximilian von Eynatten, Kevin D. Burns Kidney International Volume 86, Issue 5, Pages 1057-1058 (November 2014) DOI: 10.1038/ki.2014.246 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Urinary ACE2 protein and activity, and angiotensinogen and ACE levels during clamped euglycemia and hyperglycemia before and after treatment with empagliflozin for 8 weeks. (a) *P<0.05 vs. baseline euglycemia. †P<0.05 vs. baseline hyperglycemia. (b) *P<0.05 vs. baseline euglycemia. †P<0.05 vs. baseline hyperglycemia. (c) *P<0.05 vs. baseline euglycemia. (d) *P<0.05 vs. baseline euglycemia. †P<0.05 vs. baseline hyperglycemia. ACE, angiotensin-converting. enzyme; ELISA, enzyme-linked immunosorbent assay. Kidney International 2014 86, 1057-1058DOI: (10.1038/ki.2014.246) Copyright © 2014 International Society of Nephrology Terms and Conditions