Joanna Shepherd, Matthew C. Little, Martin J.H. Nicklin

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Presentation transcript:

Psoriasis-Like Cutaneous Inflammation in Mice Lacking Interleukin-1 Receptor Antagonist Joanna Shepherd, Matthew C. Little, Martin J.H. Nicklin Journal of Investigative Dermatology Volume 122, Issue 3, Pages 665-669 (March 2004) DOI: 10.1111/j.0022-202X.2004.22305.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Histology of cutaneous inflammation. (a) Localized lesions (arrows) in a living 155 d Il1rn-/- BALB/c male. (b–k): Formalin-fixed transverse sections of ear skin from Il1rn+/+ and Il1rn-/- BALB/c. Labels: A, microabscess; D, dermis; E, elastic cartilage; S, stratum corneum; X, subcorneal epidermis. Scale bars are 50 μm. (B–G) were stained with hematoxylin and eosin. (b) Wild-type 224 d female. (c) Unaffected Il1rn-/- male. (d) Affected 154 d Il1rn-/- male without microabscesses. (e–h) Affected Il1rn-/- mice with microabscesses. (e) 83 d female (note N, which appears to be a sloughed nucleated squame). (f) 130 d female. (g) 199 d female. (h) Well-formed microabscess from the same mouse as (e), stained for neutrophil/mast cell-specific chloroacetate esterase (magenta) and counterstained with hematoxylin. Arrows: single neutrophils in the epidermis. (i, j) Toluidine blue staining. Arrows: mast cells. (i) 174 d Il1rn–/– male. (j) 155 d wild-type female. (k) Stratum corneum of a severely affected 130 d female, as in (f), showing apparently nucleated squames (arrows). Journal of Investigative Dermatology 2004 122, 665-669DOI: (10.1111/j.0022-202X.2004.22305.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Immunodetection of CD4, DC, and vascular markers in ear pinnae. Scale bars are 50 μm. Antigen is visualized as the brown pigment. Cells were counterstained with hematoxylin. Labels: as in Figure 1. Panels a, b, e, f, h, i, k and l are from affected Il1rn-/- mice. Panels c, d, g, j, and m are taken from wild-type mice. Antibody specificity was as follows; mouse identities are in italic. (a) Lacked primary antibody (155 d male, ko1). (b) CD4 (ko1). (c) CD4 (171 d male, wt1). (d) CD205 (DC: wt1). (e) CD205 (ko1). (f) H-2IAd (MHC Class II: 224 d female, ko2). (g) H-2IAd (171 d male, wt2). (h, i) As (e), (f) respectively, arrows indicate branched cells. (j) CD31 (191 d female, wt3). (k) CD31 (ko1). (l) E-selectin (ko1). (m) E-selectin (191 d female, wt4). Journal of Investigative Dermatology 2004 122, 665-669DOI: (10.1111/j.0022-202X.2004.22305.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Immunodetection of macrophages, cytokines, and keratin 6 in ear pinnae. Scale bars are 50 μm. Antigen is indicated by the brown pigment. Cells were counterstained with hematoxylin. Labels: as in Figure 1. Tissue in panels b, c, e, f, h, and i are from affected Il1rn-/- mice. Panels a, d, g, j, k, l, and m, wild-type mice. Antibody specificity was as follows; mouse identities are in italic. (a) Lacked primary antibody (wt1). (b) IL-1β (ko1). (c) F4/80 (MΦ: ko1). (d) IL-1β (wt4). (e) IFN-γ (ko1). (f) IL-4 (ko1). (g) F4/80 (wt4). (h) IL-5 (ko1). (i) Keratin-6 (137 d male, ko3), arrow indicates collar of hair follicle. (j) IFN-γ (wt4). (k) IL-5 (wt4). (l) keratin-6 (wt2), arrows indicate follicle sheaths. (m) IL-4 (wt3). Journal of Investigative Dermatology 2004 122, 665-669DOI: (10.1111/j.0022-202X.2004.22305.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions