Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis Andrea I. Koreck, MD, PhD, Zsanett Csoma, MD, Laszlo Bodai, Ferenc Ignacz,

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Rhinophototherapy: A new therapeutic tool for the management of allergic rhinitis Andrea I. Koreck, MD, PhD, Zsanett Csoma, MD, Laszlo Bodai, Ferenc Ignacz, Anna Szabo Kenderessy, Edit Kadocsa, MD, PhD, Gabor Szabo, DSc, Zsolt Bor, DSc, Anna Erdei, DSc, Barnabas Szony, MD, PhD, Bernhard Homey, MD, Attila Dobozy, MD, DSc, Lajos Kemeny, MD, DSc Journal of Allergy and Clinical Immunology Volume 115, Issue 3, Pages 541-547 (March 2005) DOI: 10.1016/j.jaci.2004.11.005 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Effects of phototherapy on clinical symptoms of allergic rhinitis. TNS values before and after treatment in mUV/VIS irradiated and control groups (A). Changes from mean baseline values for TNS (A), sneezing, rhinorrhea, nasal itching, and nasal obstruction (B) in mUV/VIS-irradiated and control groups. Scoring of the global outcome of treatment in mUV/VIS irradiated and control groups (C). Journal of Allergy and Clinical Immunology 2005 115, 541-547DOI: (10.1016/j.jaci.2004.11.005) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Effects of phototherapy on local inflammatory cells and mediators. Comparison of changes from mean baseline values for eosinophils (A), ECP (B), and IL-5 (C) in nasal lavages of mUV/VIS-treated and control groups. The percentage of eosinophils (A), the concentration of ECP (B), and IL-5 (C) in nasal lavages before and after treatment in mUV/VIS-irradiated and control groups. Journal of Allergy and Clinical Immunology 2005 115, 541-547DOI: (10.1016/j.jaci.2004.11.005) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 In vitro effect of mUV/VIS light on T lymphocytes. Peripheral mononuclear cells were irradiated with increasing doses of mUV/VIS. Apoptosis was detected by using monoclonal antibodies specific for Apo 2.7. Three different experiments were performed. In each case, 20,000 events were acquired. Results of one of these experiments are shown. A dose-dependent increase of apoptotic T cells was detected. Journal of Allergy and Clinical Immunology 2005 115, 541-547DOI: (10.1016/j.jaci.2004.11.005) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 In vitro effect of mUV/VIS light on eosinophils. Human eosinophils separated from peripheral blood were cultured in the presence of IL-5. The cells were irradiated with increasing doses of mUV/VIS. Apoptosis was detected by using mAbs specific for Apo 2.7. In each case, 20,000 events were acquired. Three different experiments were performed. Results of one of these experiments are shown. Journal of Allergy and Clinical Immunology 2005 115, 541-547DOI: (10.1016/j.jaci.2004.11.005) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 In vitro effect of mUV/VIS light on mediator release from RBL-2H3 cells. RBL-2H3 cells sensitized with DNP-specific IgE were irradiated by using increasing doses of mUV/VIS. The results were calculated as a percentage of total β-hexosaminidase release after correction for spontaneous release of unstimulated cultures. Results are expressed as the means ± SEMs of 3 independent experiments. Journal of Allergy and Clinical Immunology 2005 115, 541-547DOI: (10.1016/j.jaci.2004.11.005) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions