Sima Margulis, Ronit Abir, Ph. D. , Carmela Felz, Shmuel Nitke, M. D

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Bone morphogenetic protein 15 expression in human ovaries from fetuses, girls, and women Sima Margulis, Ronit Abir, Ph.D., Carmela Felz, Shmuel Nitke, M.D., Haim Krissi, M.D., Benjamin Fisch, M.D., Ph.D. Fertility and Sterility Volume 92, Issue 5, Pages 1666-1673 (November 2009) DOI: 10.1016/j.fertnstert.2008.08.119 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Immunohistochemistry photographs of bone morphogenetic protein 15 (BMP-15) expression. Original magnification ×400. (A) Section of human ovary from a 33-gestational-week-old fetus with achondroplasia. Note the primordial follicles with medium red-brown staining indicating BMP-15 protein expression in the oocytes (full cytoplasmic staining without nuclear staining) and stroma cells. (B) Negative control. Section of the same ovary as in panel A. Note the primordial follicles, the overall blue staining, and the lack of red-brown staining. (C) Section of human ovary from a 5-year-old girl with abdominal neuroblastoma. Note the primary and primordial follicles with red-brown staining indicating BMP-15 protein expression in the oocytes (full cytoplasmic staining with nuclear staining) and the granulosa and stroma cells. (D) Negative control. Section of the same ovary as in panel C. Note the primary and primordial follicles, the overall blue staining, and the lack of red-brown staining. Fertility and Sterility 2009 92, 1666-1673DOI: (10.1016/j.fertnstert.2008.08.119) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 In situ hybridization photographs of bone morphogenetic protein 15 (BMP-15) expression. Original magnification ×400. (A) Section of the same ovary as in Figure 1A. Note the primordial follicles and the large primary-secondary follicle with brown staining indicating BMP-15 mRNA expression in the oocytes (full cytoplasmic staining without nuclear staining) and the granulosa and stroma cells. (B) Negative control. Section of human ovary from a 15-year-old girl with rhabdomyosarcoma. Note the primordial, primary, and primary-secondary follicles, the overall blue staining, and the lack of red-brown staining. (C) Section of human ovary from a 6-year-old girl with Hodgkin lymphoma. Note the primordial follicles with red-brown staining indicating BMP-15 mRNA expression in the granulosa and stroma cells. (D) Positive control. Section of human ovary from a 27-gestational-week-old fetus with cardiac and pulmonary abnormalities. Note the primordial follicles with red-brown staining indicating β-actin expression in the oocytes (full cytoplasmic staining with nuclear staining) and the granulosa and stroma cells. Fertility and Sterility 2009 92, 1666-1673DOI: (10.1016/j.fertnstert.2008.08.119) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions