Cellular tropism of CMV brain infection in vivo.

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Cellular tropism of CMV brain infection in vivo. Cellular tropism of CMV brain infection in vivo. Coronal murine brain sections immunostained with anti-β-galactosidase antibody display staining (green), indicative of viral infection with the lacZ-containing recombinant MCMV RM461. (A) Double immunohistochemical staining for β-galactosidase and glial fibrilary acidic protein (GFAP) (red) reveals that MCMV has a cellular tropism for astrocytes in the brain (yellow cells). (B) Double immunostaining with nestin (red) indicates that MCMV readily infects neural stem cells, seen just below the ependymal layer of the ventricules of an adult mouse. (C) Coronal section of guinea pig brain following intracerebral inoculation with an enhanced green fluorescent protein (eGFP)-expressing recombinant GPCMV (fluorescein isothiocyanate filter) demonstrating infection of cells in periventricular region. (D) Same section as in panel C following immunohistochemical staining for GFAP (red). (E) Merged image demonstrating eGFP and GFAP colocalization in astrocytes. Blue cells, DAPI (4′,6′-diamidino-2-phenylindole) stain. Maxim C.-J. Cheeran et al. Clin. Microbiol. Rev. 2009; doi:10.1128/CMR.00023-08