Fig. 3 Histomorphological evaluation of the segmental defect healing.

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Fig. 3 Histomorphological evaluation of the segmental defect healing. Histomorphological evaluation of the segmental defect healing. (A to D) Safranin Orange/von Kossa–stained thin section of a representative tibia sample in the mid-sagittal plane from each group; additional images are given in fig. S4. Scale bars, 10 mm. La, lateral; Me, medial; Pr, proximal; Di, distal, contralateral to the plate. (E) Sample harvested within the first weeks after surgery used as a control. The augmentation of the honeycombs with autologous cancellous bone graft (ABG) (remnants stained in black; marked with a blue star) and a prominent osteotomy hematoma in the central hole of the scaffold (white star) are still visible. Anne-Marie Pobloth et al., Sci Transl Med 2018;10:eaam8828 Published by AAAS