Improvement in the transcriptional activity of FOXP3A384T by enhancement of TIP60-FOXP3 interaction. Improvement in the transcriptional activity of FOXP3A384T.

Slides:

Advertisements

Similar presentations

Diminished suppressive potency of primary Treg clones from IPEXA384T patients. Diminished suppressive potency of primary Treg clones from IPEXA384T patients.

Advertisements

Treg and Teff cell subsets show increased TCR overlap during colitis.

Enhancement of Treg suppressive function by allosteric modification of TIP60. Enhancement of Treg suppressive function by allosteric modification of TIP60.

Impaired development of Treg cell function upon overexpression of FOXP3A384T in naïve CD4+CD25− T cells. Impaired development of Treg cell function upon.

Self-folding triangular devices at two scales.

TPAD controller performance for three force components.

Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis. Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis.

Three different types of transfer functions with a codomain of [0,1].

Splenic CD169+ macrophages express a unique gene profile.

Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells. Tfr cells’ transcriptomic profile distinguishes them from Treg and Tfh cells.

Workspace comparison of Delta robots.

Identification of gene modules that predict vaccination response in young or older individuals. Identification of gene modules that predict vaccination.

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Virus-specific T cell responses are detected in all MERS survivors.

Human cells produce type I and III IFNs upon Af stimulation.

Comparison of repertoire distributions to baseline.

Kinematic pattern analyses.

Tfr cells robustly secrete IL-10 after acute viral infection.

Tfr cell–derived IL-10 is important for B cell differentiation and the GC response. Tfr cell–derived IL-10 is important for B cell differentiation and.

DC subset cooperation for activation of antiviral T cells.

Fig. 7 Correlation of NHP and human ISGs.

Fig. 5 Correlation of RNA expression and protein abundance.

BAP1 deficiency results in thymic atrophy and loss of thymocyte populations. BAP1 deficiency results in thymic atrophy and loss of thymocyte populations.

Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.

Fig. 1 Cancer cell lines exhibiting homozygous deletion of MTAP show altered patterns of metabolite levels. Cancer cell lines exhibiting homozygous deletion.

Variable number of CD4-CTL precursors across donors.

CD4-CTL precursor cells in the TEMRA subset.

Fig. 1 Map of water stress and shale plays.

CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional profile. CD4+CLA+CD103+ T cells from human blood and skin share a transcriptional.

Fig. 5 MTAP status remains nonpredictive of responsiveness to nutrient restriction in a panel of tissue-matched cell lines. MTAP status remains nonpredictive.

Details of an implementation of a mechanism within the control chambers for selective lengthening of the sides of the soft robot. Details of an implementation.

Fig. 1 meR marks on E2F1 confer genome-wide effects.

CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. CD4+CLA+CD103+ T cells constitute a unique cell population in human blood. (A)

Fig. 2 IT1t prevents TLR7-mediated inflammation in pDCs.

Effects of NAT10 inhibition or depletion on gene expression.

CD25 expression identifies two transcriptionally distinct subsets of very early effector cells. CD25 expression identifies two transcriptionally distinct.

Loss of BAP1 blocks T cell differentiation at the DN3 stage in vitro.

Fig. 1 Inbred mouse strains carrying monoclonal tumors display a symmetrical yet disparate response to ICB, associated with a distinctive gene signature.

Fig. 5 EGLN2-mediated HIF1A down-regulation promotes ferroptosis.

BMS blocks functional responses in primary immune cells driven by IFNα

Fig. 3 The rs risk enhancer is a hub for intrachromosomal and interchromosomal interactions. The rs risk enhancer is a hub for intrachromosomal.

Fig. 1 Genes up-regulated in Zic5 KO cells correlate with the increased glycolytic state. Genes up-regulated in Zic5 KO cells correlate with the increased.

Map of sites with ages and postulated early and later pathways associated with modern humans dispersing across Asia during the Late Pleistocene. Map of.

Enhancement of Treg suppressive function by allosteric modification of TIP60. Enhancement of Treg suppressive function by allosteric modification of TIP60.

GPR55 mediates lymphocyte migration inhibition via Gα13.

Fig. 5 Simultaneous absence of caspase-3 and -7 is required for significant decrease of caspase-8 and -9 activation in intrinsic apoptosis. Simultaneous.

AEGIS autonomous targeting process.

Fig. 3 Transcriptional changes in dKO mice.

Partial alteration of the Treg gene signature by the p.A384T mutation.

Colonic Treg TCRs react to MA Helicobacter species.

Immune evasion occurs independently of perforin-mediated killing.

GPR55 regulates γδT cell egress from PP and homing of gut-tropic CD8 T cells to the small intestine. GPR55 regulates γδT cell egress from PP and homing.

Tregs preferentially regulate TH2 cytokines in skin.

Fig. 1 Location of the Jirzankal Cemetery.

Proprioception. Proprioception. (A) Computer-aided design (CAD) model of each component of the cylinder and the completed device with three different stiffness.

Fig. 7. Gradient of adipocyte size and FAI around the human coronaries in the presence or absence of coronary atherosclerosis. Gradient of adipocyte size.

miR-146a is highly expressed selectively on γδ27− T cells.

Fig. 4 Spatial mapping of the distribution and intensity of industrial fishing catch. Spatial mapping of the distribution and intensity of industrial fishing.

Fig. 5 Foxp3 promotes functional recruitment of Bcl11b in Treg cells.

REV-ERBα deficiency reduces frequency and number of NKp46+ ILC3s.

Fig. 1 A large number of DUBs are regulated by virus-induced type I IFN signaling at the transcriptional level. A large number of DUBs are regulated by.

REV-ERBα deficiency alters the epigenetic landscape and differentially affects clock gene expression in ILC3 subsets. REV-ERBα deficiency alters the epigenetic.

Circadian gene expression in ILC3s is associated with rhythmic cytokine expression. Circadian gene expression in ILC3s is associated with rhythmic cytokine.

Meningeal γδ T cell homeostasis is independent of inflammatory signals

Fig. 2 Daily TNC pickups and drop-offs for an average Wednesday in fall 2016 (1). Daily TNC pickups and drop-offs for an average Wednesday in fall 2016.

Neutralizing activity of mAbs isolated from plasmablasts during acute ZIKV infection in DENV-experienced donors. Neutralizing activity of mAbs isolated.

Fig. 1 TH17 cell differentiation was severely impaired in Cxxc1-deficient mice. TH17 cell differentiation was severely impaired in Cxxc1-deficient mice.

Cxxc1-deficient TH17 cells exhibit a Treg cell–like expression profile

CSGG-induced iTreg cells are capable of suppressing intestinal inflammation. CSGG-induced iTreg cells are capable of suppressing intestinal inflammation.

Fig. 2 Time series of secularization versus GDP per capita, from four illustrative countries, over the 20th century. Time series of secularization versus.

Presentation transcript:

Improvement in the transcriptional activity of FOXP3A384T by enhancement of TIP60-FOXP3 interaction. Improvement in the transcriptional activity of FOXP3A384T by enhancement of TIP60-FOXP3 interaction. FOXP3WT-, FOXP3A384T-, or empty vector–transduced cells were activated with PHA (0.5 μg/ml) for 36 hours in the presence or absence of SGF003 (8 μg/ml), followed by genome-wide microarray analysis. (A) PCA of FOXP3-regulated genes (identified in Fig. 3A) in the four indicated conditions. Component 1 (x axis) explains 65% whereas component 2 (y axis) explains 15% of the variance. (B) Heat map showing the impact of SGF treatment on the 223 FOXP3-regulated genes that are differentially expressed (P < 0.05) in untreated FOXP3WT-transduced cells versus FOXP3A384T-transduced cells. (C) The impact of SGF treatment on the expression level of 30 Treg-associated genes (shown in Fig. 3C) that are differentially expressed in FOXP3A384T-transduced cells. Khalid Bin Dhuban et al. Sci. Immunol. 2017;2:eaai9297 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.