Samina Hyder Haq, Abir Abdullah AlAmro Clinical Nutrition Experimental

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Neuroprotective effect of quercetin in murine cortical brain tissue cultures Samina Hyder Haq, Abir Abdullah AlAmro Clinical Nutrition Experimental Volume 23, Pages 89-96 (February 2019) DOI: 10.1016/j.yclnex.2018.10.002 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Percentage change of DNA fragmentation in the control, H2O2 treated, and H2O2 treatments along with 50, 100 and 150 μg/ml pre-treatments with Quercetin and Treatments with DMSO alone. Data between the groups were compared with an analysis of Variance (ANOVA) and Tukey's multiple comparison tests ***p < .0001 as compared to the control group. The readings were taken from three independent sets of experiments. Clinical Nutrition Experimental 2019 23, 89-96DOI: (10.1016/j.yclnex.2018.10.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 H&E staining of the rats brain cortical cultures. A: the control cultures. B: H2O2 treated alone. C: Cultures pre-treated with 50 μg/ml of QR for 24 h followed by induced OS by 1 mM H2O2 for 1 h. D: cultures pre-treated with 100 μg/ml of QR + 1 mM H2O2. The red arrows in B and C indicated the cytoplasmic vacuolization. Clinical Nutrition Experimental 2019 23, 89-96DOI: (10.1016/j.yclnex.2018.10.002) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Toluidine blue staining of the rats brain cortical cultures. A: the control cultures. B: H2O2 treated alone. C: Cultures pre-treated with 50 μg/ml of QR for 24 h followed by induced OS by 1 mM H2O2 for 1 h. D: cultures pre-treated with 100 μg/ml of QR + 1 mM H2O2. Note in B the neuronal cell undergoes necrosis and pyknosis with no surrounding cytoplasm. The arrow in picture C shows only few normal neuron cells which were left after H2O2 treatment as compared to picture D where the pre-treatment with 100 μg/ml of QR resulted in ameliorated the OS induced by H2O2. Clinical Nutrition Experimental 2019 23, 89-96DOI: (10.1016/j.yclnex.2018.10.002) Copyright © 2018 The Authors Terms and Conditions